Jayanath, Subhashini and Fong, Choong Yi and Sarvananthan, Rajini (2021) Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia. Research in Autism Spectrum Disorders, 84. ISSN 1750-9467, DOI https://doi.org/10.1016/j.rasd.2021.101786.
Full text not available from this repository.Abstract
Background: Determine the prevalence and risk factors of vitamin D deficiency (<35 nmol/L) in children with autism spectrum disorder (ASD); and explore the association between vitamin D deficiency with ASD severity and behavioural symptoms. Method: Cross-sectional study of children with ASD at a tertiary hospital. Children with vitamin D deficiency (<35.0 nmol/L) were treated (1200IU cholecalciferol, daily for 3 months). ASD severity was determined via the Childhood Autism Rating Scale, 2nd Edition (CARS-2); and behavioural symptoms via the Aberrant Behaviour Checklist, 2nd Edition (ABC-2). Scores were compared between the vitamin D deficient and non-deficient groups. Results: There were 103 participants (85.4 % male). Mean age: 6.2 years (SD = 2.4), 19 % were vitamin D deficient and 42 % were insufficient. Mean vitamin D concentration was 45.8 nmol/L (SD = 13.5). Female gender was significantly associated with vitamin D deficiency (OR 5.05, 95 % CI: 1.56, 16.31, p = 0.007). Post-vitamin D treatment, there was a significant reduction in CARS-2 scores (p < 0.05), but not ABC-2 scores. Conclusions: Nearly two-thirds (61 %) of Malaysian children with ASD have vitamin D deficiency (19 %) and insufficiency (42 %). Vitamin D treatment among vitamin D deficient children with ASD resulted in improvement in ASD symptom severity but not behavioural symptoms.
| Item Type: | Article |
|---|---|
| Funders: | University Malaya Specialist Centre (UMSC CARE Fund) (PV017-2018) |
| Uncontrolled Keywords: | Autism; Vitamin D; Children; Childhood Autism Rating Scale; Aberrant Behaviour Checklist |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 11 Mar 2022 04:53 |
| Last Modified: | 11 Mar 2022 04:53 |
| URI: | http://eprints.um.edu.my/id/eprint/27073 |
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