Riazalhosseini, Behnaz and Mohamed, Rosmawati and Apalasamy, Yamunah Devi and Mohamed, Zahurin (2021) Association of deleted in liver cancer-1 gene polymorphism with increased risk of chronicity of disease among Malaysian patients with hepatitis B infection. Pharmacogenetics and Genomics, 31 (9). pp. 185-190. ISSN 1744-6872, DOI https://doi.org/10.1097/FPC.0000000000000439.
Full text not available from this repository.Abstract
Objective The aim of this study is to examine the association between genetic variations in deleted in liver cancer 1 (DLC1) gene with progression of the hepatitis B virus (HBV) infection. Methods A total of 623 subjects were included in this study, of whom, 423 were chronic hepatitis B (CHB) patients without liver cirrhosis or hepatocellular carcinoma (HCC), 103 CHB with either liver cirrhosis +/- HCC and 97 individuals who had resolved HBV. Two single-nucleotide polymorphisms rs3739298 and rs532841 of DLC1 gene were genotyped using the Sequenom MassARRAY platform. Results Our results indicated significant differences between the chronic HBV and resolved HBV groups in genotype and allele frequencies of DLC1-rs3739298 odds ratio (OR) = 2.23; 95% confidence interval (CI): 1.24-3.99; P = 0.007] and (OR = 1.54; 95% CI: 1.07-2.22; P = 0.021), respectively. Moreover, haplotype analysis revealed significant associations between chronicity of HBV with TG and GA haplotypes (P = 0.041 and P = 0.042), respectively. Conclusion A significant association exists between the rs3739298 variant and susceptibility to CHB infection.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Chronic hepatitis B; Deleted in liver cancer 1 gene; Hepatocellular carcinoma; Liver cirrhosis; Single-nucleotide polymorphism |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > School of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 23 Feb 2022 08:07 |
| Last Modified: | 23 Feb 2022 08:07 |
| URI: | http://eprints.um.edu.my/id/eprint/26359 |
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