Proliferative and apoptotic activity at the tumour invasive front in oral squamous cell carcinoma

Ngeow, Wei Cheong and Zain, R.B. and Abidin, Z. and Phaik, K.S. and Kumar, S. (2005) Proliferative and apoptotic activity at the tumour invasive front in oral squamous cell carcinoma. Oral Oncology, 1 (1). pp. 150-151. ISSN 1368-8375, DOI https://doi.org/10.1016/s1744-7895(05)80383-9.

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Abstract

Introduction: the tumour invasive front of squamous cell carcinoma (OSCC) has long been recognized as an important area which harbour prognostic information. The aim of the present study was to describe the expression of K1-67, MDM2 and Bcl-2 at the tumour invasive front in the buccal mucosa and also to investigate whether there is any association between the expression of K1-67, MDM2 and Bcl-2 with the certain sociodemographic characteristics, clinical and histopathological parameters. Materials and Methods: The sample of this study consisted of 31 biopsy cases of OSCC from the buccal mucosa. Immunohistochemistry was used with specific antibodies to K1-67, MDM2 and Bcl-2. Evaluation of the nuclear immunoreactivity of all K1-67, MDM2 and Bcl-2 was done at the tumour invasive front (3-6 cell layers at the tumour advancing front). Results: The expression of K1-67, MDM2 and Bcl-2 were detected in 90.3% (28), 64.5% (20) and 16.1% (5) of the cases respectively. The distribution of K1-67 and Bcl-2 immunoreactivity was observed to be quite similar where immunoreactivity was mainly at peripheral invading margin of tumour cell islands with decreasing immunoreactivity towards the centre. The distribution of MDM2 immunoreactivity was unlike that K1-67 and Bcl-2 where the immunoreactivity was observed mainly at the suprabasal region. The present study found significant association between MDM2 expression with gender and Broder’s tumour grading. Significant association was also observed between combined K1-67/MDM2 expression with both gender and Broder’s tumour grading. Conclusion: The present study appeared to suggest no significant association between K1-67, MDM2 and Bcl-2 at the tumour invasive front. No association was also found between k1-67 expression as a proliferative marker and both MDM2 and Bcl-2 as apoptotic markers. However, it appeared to support the observation from the previous study that an increase carcinoma proliferation rate would also be accompanied by an increase in apoptosis.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Department of Oral Pathology and Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya
Uncontrolled Keywords:	Oral squamous cell carcinoma, OSCC, lichenoid lesions, lichen planus, oral cancer, oral tumours, pemphigus, traumatic eosinophilic granuloma, aphthous ulcers, oral mucosal lesions, betel chewers mucosa, betel quid related lesions, betel quid, areca quid, tobacco quid, oral cancer screening, training and calibration, early detection, oral cancer awareness, biobanking, tissue bank, databank, oral cancer, tissue bank, research credibility, research ethics
Subjects:	R Medicine > RK Dentistry > Oral surgery
Divisions:	Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User:	Prof. Dr. Rosnah Mohd Zain
Date Deposited:	13 Feb 2012 01:23
Last Modified:	13 Nov 2019 02:29
URI:	http://eprints.um.edu.my/id/eprint/2607

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