Proliferating cell nuclear antigen (PCNA) expression in oral squamous cell carcinoma - an aid to conventional histological grading?

Zain, R.B. and Sakamoto, F. and Shrestha, P. and Mori, M. (1995) Proliferating cell nuclear antigen (PCNA) expression in oral squamous cell carcinoma - an aid to conventional histological grading? The Malaysian Journal of Pathology, 17 (1). pp. 23-30. ISSN 0126-8635

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Abstract

Proliferating cell nuclear antigen (PCNA) is a well known marker for cell proliferation. It tends to accumulate in the late G1 and S-phase of the cell cycle. A monoclonal antibody (MoAb) against PCNA is now available and it can react with paraffin-embedded specimens. In the present study, PCNA immunohistochemical staining of 36 cases of oral cancer specimens obtained from surgery were investigated. The results showed differing nuclear staining patterns for PCNA in normal, hyperplastic and dysplastic epithelium, early cancer and 3 levels of differentiation for squamous cell carcinoma of the oral cavity. It appears that PCNA can be a useful marker in delineating normal epithelium and hyperplastic epithelium from dysplasia in the oral cavity. The use of PCNA staining may further emphasize the conventional histopathological grading of well-differentiated, moderately-differentiated and poorly-differentiated oral squamous cell carcinoma but is still dependent on basic criteria as observed without immunostaining. PCNA expression for all grades of squamous cell carcinoma are present at the deep, infiltrative margins.

Item Type: Article
Additional Information: Department of Oral Pathology and Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya
Uncontrolled Keywords: Carcinoma, Squamous Cell; Epithelium; Humans; Hyperplasia; Leukoplakia, Oral; Mouth Mucosa; Mouth Neoplasms; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Tumor Markers, Biological
Subjects: R Medicine > RK Dentistry > Oral surger
Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User: Prof. Dr. Rosnah Mohd Zain
Date Deposited: 13 Feb 2012 01:21
Last Modified: 21 Oct 2014 00:32
URI: http://eprints.um.edu.my/id/eprint/2606

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