Wong, Sui Weng and Ting, Yi Wen and Yong, Yean Kong and Tan, Hong Yien and Barathan, Muttiah and Riazalhosseini, Behnaz and Bee, Chook Jack and Tee, Kok Keng and Larsson, Marie and Velu, Vijayakumar and Shankar, Esaki Muthu and Mohamed, Rosmawati (2021) Chronic inflammation involves CCL11 and IL-13 to facilitate the development of liver cirrhosis and fibrosis in chronic hepatitis B virus infection. Scandinavian Journal of Clinical & Laboratory Investigation, 81 (2). pp. 147-159. ISSN 0036-5513, DOI https://doi.org/10.1080/00365513.2021.1876245.
Full text not available from this repository.Abstract
The pathogenesis involving non-alcoholic fatty liver disease (NAFLD) in the context of chronic HBV (CHB) virus infection requires to be understood for developing improved modalities of diagnosis and treatment. We retrospectively investigated the association between NAFLD and CHB virus infection in the context of liver fibrosis. Among the 522 consecutive CHB patients who underwent transient elastography between years 2013 and 2016, we studied 455 subjects in the current investigation. Controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) scores were generally higher in patients with steatosis and fibrosis or cirrhosis. Antiviral treatment had significantly reduced the hepatitis B virus (HBV) viral load. Other liver function markers showed a significant positive correlation with both CAP and LSM scores. Plasma IL-13 was independently associated with increased CAP score where every increase of 1 unit of IL-13 was associated with an increase in CAP score by 0.98 unit. CCL11 was independently associated with LSM with every increase of CCL11 by a unit that, in turn, was associated with an increase of LSM score. We found that there was a high concurrence of NAFLD among patients with CHB virus infection. The presence of metabolic syndrome and chronic inflammation in CHB virus-infected patients were two independent factors that led to the progression of liver cirrhosis, with IL-13 playing the key role in linking the metabolic with the inflammatory components. © 2021 Medisinsk Fysiologisk Forenings Forlag (MFFF).
| Item Type: | Article |
|---|---|
| Funders: | Frontier Research Grant (FRG), [FG019-17AFR], Xiamen University Malaysia Research Funding (XMUMRF), [XMUMRF/2018-C2/ILAB/0001], Swedish Research Council, the Swedish Physicians against AIDS Research Foundation, VINNMER for Vinnova, Linköping University Hospital Research Fund, ALF Grants Region Östergötland, FORSS, Department of Science and Technology-Science and Engineering Research Board, Government of India (Grant number CRG/2019/006096) |
| Uncontrolled Keywords: | CCL11; Fibrosis; HBV; IL-13; metabolic syndrome |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 May 2021 07:19 |
| Last Modified: | 03 May 2021 07:19 |
| URI: | http://eprints.um.edu.my/id/eprint/25928 |
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