Profiling of Potential Antibacterial Compounds of Lactic Acid Bacteria against Extremely Drug Resistant (XDR) Acinetobacter baumannii

Yap, Phui Chyng and Ayuhan, Noorfazlin and Woon, Jia Jie and Teh, Cindy Shuan Ju and Lee, Vannajan Sanghiran and Azman, Adzzie Shazleen and AbuBakar, Sazaly and Lee, Hai Yen (2021) Profiling of Potential Antibacterial Compounds of Lactic Acid Bacteria against Extremely Drug Resistant (XDR) Acinetobacter baumannii. Molecules, 26 (6). p. 1727. ISSN 1420-3049

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Official URL: https://doi.org/10.3390/molecules26061727

Abstract

A total of 20 of isolates of lactic acid bacteria (LAB) were selected and screened for antagonistic activity against clinical strains of 30 clinical isolates of extremely drug-resistant (XDR) Acinetobacter baumannii using the well diffusion assay method. Results showed that 50% of the highly LAB strains possessed inhibitory activity against (up to 66%) of the XDR A. baumannii strains tested. The supernatant of the twenty LAB strains was subjected to gas chromatography mass spectrometry (GCMS) revealed that the common compound found in the active isolates against XDR A. baumannii was 3-Isobutyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, a known potential diketopiperazine group. The molecular docking study against potential antibacterial targets with selected ligands was performed to predict the binding mode of interactions, which is responsible for antibacterial activity. The docking analysis of the potent compounds supported the potential antibacterial activity exhibiting high inhibition constant and binding affinity in silico.

Item Type: Article
Uncontrolled Keywords: infectious diseases; antimicrobial resistance (AMR); lactic acid bacteria; Malaysia; diketopiperazine (DKP)
Subjects: Q Science > QD Chemistry
R Medicine
Divisions: Faculty of Medicine
Faculty of Science > Dept of Chemistry
Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 30 Apr 2021 01:29
Last Modified: 30 Apr 2021 01:29
URI: http://eprints.um.edu.my/id/eprint/25908

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