Elevated Serum Transforming Growth Factor β1 Levels in Epstein-Barr Virus-Associated Diseases and Their Correlation with Virus-Specific Immunoglobulin A (IgA) and IgM

Xu, Jingwu and Ahmad, Ali and Jones, James F. and Dolcetti, Riccardo and Vaccher, Emanuela and Prasad, Umapati and Menezes, José (2000) Elevated Serum Transforming Growth Factor β1 Levels in Epstein-Barr Virus-Associated Diseases and Their Correlation with Virus-Specific Immunoglobulin A (IgA) and IgM. Journal of Virology, 74 (5). pp. 2443-2446. ISSN 0022-538X

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Official URL: https://doi.org/10.1128/JVI.74.5.2443-2446.2000

Abstract

Transforming growth factor β (TGF-β) is an immunosuppressive cytokine which can induce immunoglobulin A (IgA) switch and Epstein-Barr virus (EBV) replication in latently infected cells. Here we report elevated serum levels of TGF-β in various EBV-associated diseases correlating positively with EBV- specific IgA titers and negatively with IgM titers, suggesting a role for this cytokine in the pathogenesis of these diseases.

Item Type: Article
Uncontrolled Keywords: Antibodies, Viral; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Immunoglobulin A; Immunoglobulin M; Regression Analysis; Transforming Growth Factor beta
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 12 Apr 2021 02:01
Last Modified: 12 Apr 2021 02:01
URI: http://eprints.um.edu.my/id/eprint/25856

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