Yap, Alvin Chee Sum and Li, Xiaojie and Yap, Yeannie Hui Yeng and Razif, Muhammad Fazril Mohamad and Abd Jamil, Amira Hajirah and Ng, Szu Ting and Tan, Chon Seng and Cheung, Peter Chi Keung and Fung, Shin Yee (2020) Immunomodulatory Properties of Water-Soluble Polysaccharides Extracted from the Fruiting Body of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis Cultivar OCS02® (Ascomycetes). International Journal of Medicinal Mushrooms, 22 (10). pp. 967-977. ISSN 1521-9437, DOI https://doi.org/10.1615/IntJMedMushrooms.2020036351.
Full text not available from this repository.Abstract
Ophiocordyceps sinensis (=Cordyceps sinensis) has been known for its various medicinal properties, in particular immunomodulatory activities associated with its polysaccharides. In this study, the fruiting body of O. sinensis cultivar OCS02® was investigated for its chemical composition and monosaccharide profile. Cold water extract (CWE) obtained from this fruiting body was fractionated by molecular weight (MW) into high (HMW), medium (MMW), and low (LMW) fractions. Polysaccharides in the extract and fractions were identified as heteroglycans containing mostly glucose and mannose with small amounts of galactose, fucose, arabinose, and xylose. The immunomodulatory potential of these heteroglycans was evaluated by induction of cytokine/chemokine secretion using murine macrophage RAW 264.7. All treatments showed significant modulation of IL-6, IL-9, MIP-2, and TIMP-1, especially for CWE, HMW, and MMW, which might be due to their high ratios of glucose and the presence of protein. Further investigation on the structure–function relationship of these fruiting body polysaccharide fractions is needed to delineate the underlying mechanism of their immunomodulatory effect both in vitro and in vivo. © 2020 by Begell House, Inc.
| Item Type: | Article |
|---|---|
| Funders: | Fundamental Research Grant Scheme (FRGS): FP044-2018A (FRGS/1/2018/SKK08/UM/02/19), SATU Grant ST001-2019, MAHSA University Research Grant RP122-0917 |
| Uncontrolled Keywords: | Ophiocordyceps sinensis; immunomodulation; cytokine; medicinal mushrooms; polysaccharide |
| Subjects: | R Medicine R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 Feb 2021 03:23 |
| Last Modified: | 26 Feb 2021 03:23 |
| URI: | http://eprints.um.edu.my/id/eprint/25774 |
Actions (login required)
 |
View Item |
