Yeoh, Fang Hoong and Lee, Choy Sin and Kang, Yew Beng and Wong, Shew Fung and Cheng, Sit Foon and Ng, Wei Seng (2020) Production of Biodegradable Palm Oil-Based Polyurethane as Potential Biomaterial for Biomedical Applications. Polymers, 12 (8). p. 1842. ISSN 2073-4360, DOI https://doi.org/10.3390/POLYM12081842.
Full text not available from this repository.Abstract
Being biodegradable and biocompatible are crucial characteristics for biomaterial used for medical and biomedical applications. Vegetable oil-based polyols are known to contribute both the biodegradability and biocompatibility of polyurethanes; however, petrochemical-based polyols were often incorporated to improve the thermal and mechanical properties of polyurethane. In this work, palm oil-based polyester polyol (PPP) derived from epoxidized palm olein and glutaric acid was reacted with isophorone diisocyanate to produce an aliphatic polyurethane, without the incorporation of any commercial petrochemical-based polyol. The effects of water content and isocyanate index were investigated. The polyurethanes produced consisted of > 90% porosity with interconnected micropores and macropores (37-1700 μm) and PU 1.0 possessed tensile strength and compression stress of 111 kPa and 64 kPa. The polyurethanes with comparable thermal stability, yet susceptible to enzymatic degradation with 7-59% of mass loss after 4 weeks of treatment. The polyurethanes demonstrated superior water uptake (up to 450%) and did not induce significant changes in pH of the medium. The chemical changes of the polyurethanes after enzymatic degradation were evaluated by FTIR and TGA analyses. The polyurethanes showed cell viability of 53.43% and 80.37% after 1 and 10 day(s) of cytotoxicity test; and cell adhesion and proliferation in cell adhesion test. The polyurethanes produced demonstrated its potential as biomaterial for soft tissue engineering applications. © 2020 by the authors.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education (MOHE), Malaysia, Exploratory Research Grant Scheme (ERGS) (ERGS/1/2012/TK04 /IMU/03/1), International Medical University, Bukit Jalil, Malaysia |
| Uncontrolled Keywords: | Biocompatible; Biodegradable; Biomaterial; Palm oil-based polyester polyol; Polyurethane; Tissue engineering |
| Subjects: | Q Science > QD Chemistry R Medicine |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Feb 2021 06:55 |
| Last Modified: | 18 Feb 2021 06:55 |
| URI: | http://eprints.um.edu.my/id/eprint/25762 |
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