Zeimaran, Ehsan and Pourshahrestani, Sara and Nam, Hui Yin and Razak, Nasrul Anuar Abd and Kalantari, Katayoon and Kamarul, Tunku and Salamatinia, Babak and Kadri, Nahrizul Adib (2020) Engineering stiffness in highly porous biomimetic gelatin/tertiary bioactive glass hybrid scaffolds using graphene nanosheets. Reactive and Functional Polymers, 154. p. 104668. ISSN 1381-5148, DOI https://doi.org/10.1016/j.reactfunctpolym.2020.104668.
Full text not available from this repository.Abstract
Class II organic-inorganic hybrid materials have emerged as a promising replacement for the conventional bioactive glass particle-polymer composite biomaterials. Although these materials benefit from several advantages, such as controlled congruent degradation and improved cell response compared with the conventional composites, they become brittle when the inorganic-to-organic ratio exceeds an optimum value, rendering them unsuitable for tissue engineering applications. Here, a series of hybrid composite scaffolds were prepared from gelatin, tertiary bioactive glass and graphene oxide (GO) using a sol-gel/gas foaming technique. This study shows that rather than increasing the inorganic concentration to increase the mechanical stiffness, a small amount of GO (1 and 2 wt%) can be used to remarkably improve the Young's modulus of hybrid materials, by about 200%, without deteriorating the strain to failure. The hybrid scaffolds underwent a linear biodegradation, and a remarkable bioactivity reflected in a thick layer of hydroxyapatite formed on their surfaces after 14 days of immersion in carbonate buffered Dulbecco's modified Eagle's medium. The excellent biocompatibility of these scaffolds towards human adipose-derived mesenchymal stromal cells was confirmed in vitro. GO-doped organic-inorganic hybrid composite scaffolds may be ideal materials for a range of tissue engineering applications such as interface and non-load bearing bone tissue engineering. © 2020 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education of Malaysia, FRGS grant number: FP076-2018A, University of Malaya through grant number: GPF030A-2018 |
| Uncontrolled Keywords: | Organic-inorganic hybrid; Graphene oxide; Bioactive glass; Bioactivity; Tissue engineering |
| Subjects: | R Medicine |
| Divisions: | Faculty of Engineering Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Jan 2021 07:05 |
| Last Modified: | 20 Jan 2021 07:05 |
| URI: | http://eprints.um.edu.my/id/eprint/25705 |
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