Gan, Chew Yan and Low, Yun Yee and Etoh, Tadahiro and Hayashi, Masahiko and Komiyama, Kanki and Kam, Toh Seok (2009) Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis. Journal of Natural Products, 72 (12). pp. 2098-2103. ISSN 0163-3864, DOI https://doi.org/10.1021/np900576b.
Full text not available from this repository.Abstract
Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 also by partial synthesis. Alkaloids 1-5 reversed multidrug resistance in vincristine-resistant KB cells. © 2009 American Chemical Society and American Society of Pharmacognosy.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Humans; Indole Alkaloids; KB Cells; Malaysia; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Bark; Plant Stems; Stereoisomerism; Vincristine |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Dec 2020 05:34 |
| Last Modified: | 14 Dec 2020 05:34 |
| URI: | http://eprints.um.edu.my/id/eprint/25657 |
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