Characterization and optimization of the mechanical properties of electrospun gelatin nanofibrous scaffolds

Nuge, Tamrin and Tshai, Kim Yeow and Lim, Siew Shee and Nordin, Norshariza and Hoque, Md Enamul (2020) Characterization and optimization of the mechanical properties of electrospun gelatin nanofibrous scaffolds. World Journal of Engineering, 17 (1). pp. 12-20. ISSN 1708-5284

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Official URL: https://doi.org/10.1108/WJE-04-2019-0119

Abstract

Purpose: Electrospinning is a versatile technique for producing polymeric nanofibers by the application of electrostatic forces. The electrospinnability of polymeric solutions and the properties of electrospun nanofibers can be influenced and tuned by the process parameters. This paper aims to investigatethe influence of three key process parameters on the tensile strength of electrospun gelatin nanofibrous scaffold. Design/methodology/approach: The experiments were conducted with a custom-built electrospinning system. Design of experiments of the three operating variables, namely, gelatin concentration, applied potential and feed rate, with five levels were investigated. Optimization of the tensile strength of electrospun gelatin scaffold was achieved with the aid of response surface methodology. Findings: The resulting second-order mathematical models capable of demonstrating good correlation on the effects of the three identified process parameters with the experimental measured tensile strength, where the highest tensile strength was obtained on gelatin nanofibrous scaffold electrospun at 16per cent (w/v) gelatin concentration in acetic acid, 19 kV applied potential and 0.31 ml/h feed rate. Originality/value: The resulting second-order mathematical models capable of demonstrating good correlation on the effects of the three identified process parameters with the experimental measured tensile strength, where the highest tensile strength was obtained on gelatin nanofibrous scaffold electrospun at 16per cent (w/v) gelatin concentration in acetic acid, 19 kV applied potential and 0.31 ml/h feed rate. © 2020, Emerald Publishing Limited.

Item Type: Article
Uncontrolled Keywords: Electrospinning; Mechanical properties; Nanofibers; Response surface methodology
Subjects: T Technology > TJ Mechanical engineering and machinery
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 07 Sep 2020 02:25
Last Modified: 07 Sep 2020 02:25
URI: http://eprints.um.edu.my/id/eprint/25513

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