Pitisuttithum, Panyavee and Chan, Wah Kheong and Piyachaturawat, Panida and Imajo, Kento and Nakajima, Atsushi and Seki, Yosuke and Kasama, Kazunori and Kakizaki, Satoru and Fan, Jian Gao and Song, Myeong Jun and Yoon, Seung Kew and Dan, Yock Young and Lesmana, Laurentius and Ho, Khek Yu and Goh, Khean Lee and Wong, Vincent Wai Sun and Treeprasertsuk, Sombat (2020) Predictors of advanced fibrosis in elderly patients with biopsy-confirmed nonalcoholic fatty liver disease: the GOASIA study. BMC Gastroenterology, 20 (1). p. 88. ISSN 1471-230X, DOI https://doi.org/10.1186/s12876-020-01240-z.
Full text not available from this repository.Abstract
Background: The Gut and Obesity in Asia (GOASIA) Workgroup was formed to study obesity and gastrointestinal diseases in the Asia Pacific region. We aimed to 1) compare the characteristics of elderly (i.e. age ≥ 60) vs. non-elderly patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD); 2) identify predictors of advanced fibrosis in elderly patients with NAFLD; and 3) assess the performance of non-invasive fibrosis scores in the prediction of advance fibrosis in the elderly population. Methods: We abstracted the data of 1008 patients with NAFLD from nine centers across eight countries. Characteristics of elderly and non-elderly patients with NAFLD were compared using 1:3 sex-matched analysis. Results: Of the 1008 patients, 175 were elderly [age 64 (62-67) years], who were matched with 525 non-elderly patients [46 (36-54) years]. Elderly patients were more likely to have advanced fibrosis (35.4% vs. 13.3%; p < 0.001). By multivariable analysis, factors associated with advanced fibrosis in elderly patients included female sex [odds ratio (OR) 3.21; 95% confidence interval (CI) 1.37-7.54] and hypertension (OR 3.68; 95%CI 1.11-12.23). The area under receiver-operating characteristics curve (95% CI) of aspartate aminotransferase-to-platelet ratio index, NAFLD fibrosis score and Fibrosis-4 index for predicting advanced fibrosis in elderly patients were 0.62 (0.52-0.72), 0.65 (0.55-0.75) and 0.64 (0.54-0.74) respectively. Conclusions: Elderly patients with NAFLD had a higher prevalence of advanced fibrosis than non-elderly patients. Female and hypertension were predicting factors for advanced fibrosis in the elderly. Non-invasive fibrosis scores had a lower specificity in elderly. © 2020 The Author(s).
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Advanced fibrosis; Elderly patients; Nonalcoholic fatty liver disease (NAFLD) |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Aug 2020 06:26 |
| Last Modified: | 18 Aug 2020 06:26 |
| URI: | http://eprints.um.edu.my/id/eprint/25396 |
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