Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications

Pouran, Shima Rahim and Bayrami, Abolfazl and Arvanag, Farid Mohammadi and Habibi-Yangjeh, Aziz and Soltani, Reza Darvishi Cheshmeh and Ramesh, Singh and Abdul Raman, Abdul Aziz and Chae, Keun Hwa and Khataee, Alireza and Kang, Hee Kyoung (2020) Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications. Colloids and Surfaces B: Biointerfaces, 189. p. 110878. ISSN 0927-7765

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Official URL: https://doi.org/10.1016/j.colsurfb.2020.110878

Abstract

In this research, a milk thistle seed extract (MTSE)-rich medium was used as a capping and reducing agent for the one-pot biosynthesis of ZnO/Ag (5 wt%) nanostructure. The sample was systematically characterized through various techniques and its strong biomolecule‒metal interface structure was supported by the results. The efficacy of the derived nanostructure (MTSE/ZnO/Ag) was evaluated in vivo on the basis of its therapeutic effects on the main complications of Type 1 diabetes (hyperglycemia, hyperlipidemia, and insulin deficiency). For this purpose, the changes in the plasma values of fasting blood glucose, total cholesterol, total triglyceride, high-density lipoprotein cholesterol, and insulin in alloxan-diabetic Wistar male rats were compared with those in healthy and untreated diabetic controls after a treatment period of 16 days. The antidiabetic results of MTSE/ZnO/Ag were compared with those obtained from pristine ZnO, MTSE, and insulin therapies. The health conditions of the rats with Type 1 diabetes were significantly enhanced after treatment with MTSE/ZnO/Ag (p < 0.05), which is owing to the enhanced interface structure and participatory functions of the united compartments of MTSE/ZnO/Ag. © 2020

Item Type: Article
Uncontrolled Keywords: Bio-metal interface; Hyperglycemia; Hyperlipidemia; Silymarin; Type 1 diabetes
Subjects: T Technology > TJ Mechanical engineering and machinery
T Technology > TP Chemical technology
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 14 Aug 2020 05:48
Last Modified: 14 Aug 2020 05:48
URI: http://eprints.um.edu.my/id/eprint/25360

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