Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity

Chong, Y.M.; Yin, W.F.; Ho, C.Y.; Mustafa, M.R.; Hadi, A.H.A.; Awang, K.; Narrima, P.; Koh, C.L. (2011) Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity. Journal of Natural Products, 74 (10). pp. 2261-2264.

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    Abstract

    A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further

    Item Type: Article
    Creators:
    1. Chong, Y.M.
    2. Yin, W.F.
    3. Ho, C.Y.
    4. Mustafa, M.R.
    5. Hadi, A.H.A.
    6. Awang, K.
    7. Narrima, P.
    8. Koh, C.L.
    Journal or Publication Title: Journal of Natural Products
    Additional Information: Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Uncontrolled Keywords: Malabaricone C
    Subjects: Q Science > Q Science (General)
    Q Science > QD Chemistry
    R Medicine > RM Therapeutics. Pharmacology
    Divisions: Faculty of Science
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 30 Jan 2012 10:03
    Last Modified: 11 Dec 2014 16:35
    URI: http://eprints.um.edu.my/id/eprint/2521

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