Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity

Chong, Y.M. and Yin, W.F. and Ho, C.Y. and Mustafa, Mohd Rais and Hadi, A.H.A. and Awang, K. and Narrima, P. and Koh, C.L. (2011) Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity. Journal of Natural Products, 74 (10). pp. 2261-2264.

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Abstract

A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further

Item Type: Article
Additional Information: Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
Uncontrolled Keywords: Malabaricone C
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 30 Jan 2012 02:03
Last Modified: 18 Dec 2019 06:37
URI: http://eprints.um.edu.my/id/eprint/2521

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