Chong, Y. M.; Yin, W. F; Ho, C. Y.; Mustafa, M. R.; Hadi , A.H. A.; Awang, K.; Narrima, P.; Koh, C L (2011) Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity. Journal of Natural Products, 74 (10). pp. 2261-2264.
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Abstract
A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further
| Item Type: | Article |
|---|---|
| Creators: | |
| Journal or Publication Title: | Journal of Natural Products |
| Additional Information: | Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia |
| Uncontrolled Keywords: | Malabaricone C |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Science |
| Depositing User: | Ms Haslinda Lahuddin |
| Date Deposited: | 30 Jan 2012 10:03 |
| Last Modified: | 30 Jan 2012 10:03 |
| URI: | http://eprints.um.edu.my/id/eprint/2521 |
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