Statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension

Saat, Muhammad Naziz and Annuar, Mohamad Suffian Mohamad (2020) Statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension. Biocatalysis and Agricultural Biotechnology, 23. p. 101464. ISSN 1878-8181

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Official URL: https://doi.org/10.1016/j.bcab.2019.101464

Abstract

One-pot synthesis of oligomeric sugar ester was carried out by lipase-catalyzed esterification of ε-caprolactone (ECL) with methyl-d-glucopyranoside (MGP) followed by the chain extension of ECL monomer/oligomer. Two-level half fractional factorial design was employed to analyse the effects of selected operating variables namely lipase loading (1.2–2.8% w/v), initial ECL (3.8–11.5% w/v), initial MGP (0.04–0.14% w/v), temperature (40–60 °C) and agitation (90–180 rpm) as a function of maximum dry weight (% w/v) of MGP-6-O-oligo-ECL. It was found that individual variables viz. lipase loading, initial ECL and temperature affect the maximum product formation. The interaction effects between variables indicated the presence of relationship among them. Spectroscopic authentication showed the presence of covalent bond between the hydroxyl group of MGP with carboxylic acid end group of ECL monomer/oligomer. Thermal analysis indicated three degradation stages of functionalized oligomer. The molecular weight analysis of the functionalized oligomer was observed at 1655 g mol−1 with narrow PDI value of 1.36. Conversion of initial ECL was 90% compared to 14% of initial MGP. © 2019 Elsevier Ltd

Item Type: Article
Uncontrolled Keywords: Enzyme reactor; Functionalization; Half fractional factorial design; Living polymerization; Oligomeric sugar ester; One-pot synthesis
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 28 Jul 2020 03:28
Last Modified: 28 Jul 2020 03:28
URI: http://eprints.um.edu.my/id/eprint/25207

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