Fahim, Ayesha and Himratul-Aznita, Wan Harun and Abdul-Rahman, Puteri Shafinaz (2020) Allium-sativum and bakuchiol combination: A natural alternative to Chlorhexidine for oral infections? Pakistan Journal of Medical Sciences, 36 (2). pp. 271-275. ISSN 1682-024X, DOI https://doi.org/10.12669/pjms.36.2.1457.
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Abstract
Objective: Chlorhexidine mouthrinses are considered a gold standard as an adjunct treatment of oral infections. However, owing to its toxicity, discoloration of tooth surface and the emerging prevalence of drug-resistant species, attention is being given to exploring natural alternatives to the drug. Methods: The experiment was carried out in Azra Naheed Center for Research and Development (ANCRD), Superior University, Lahore, Pakistan from September 2018 till May 2019. Biofilms and planktonic cells of C. albicans alone and in combination with streptococci were subjected to chlorhexidine, allium sativum and bakuchiol individually and to allium-bakuchiol combination. Kirby-Bauer test, antifungal susceptibility testing, CFU count and drug synergy assessment was done on planktonic cells. Dynamic biofilms were formed to mimic conditions similar to oral cavity and CFU was determined. Results: MIC of all three agents was higher against mixed species when compared to single species planktonic cells and biofilm. Allium sativum and bakuchiol demonstrated synergistic effects. The decrease in CFU count and minimum biofilm reduction to salivary pellicle caused by allium sativum-bakuchiol was comparable to that of chlorhexidine. Conclusion: Thus, allium sativum-bakuchiol combination demonstrated antimicrobial effects similar to chlorhexidine against planktonic cells and dynamic biofilm. It could serve as a possible natural, economical alternative to chlorhexidine mouthrinses usually recommended in dental clinics. However, in vivo studies are required to determine the correct dosage of these agents.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Allium sativum; Bakuchiol; Candida; Chlorhexidine; Streptococci |
| Subjects: | R Medicine > RK Dentistry > Practice of dentistry. Dental economics |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Mr Ahmad Azwan Azman |
| Date Deposited: | 13 Jul 2020 02:29 |
| Last Modified: | 13 Jul 2020 02:29 |
| URI: | http://eprints.um.edu.my/id/eprint/25006 |
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