Benzimidazolium-acridine-based silver N-heterocyclic carbene complexes as potential anti-bacterial and anti-cancer drug

Sharhan, Olla and Heidelberg, Thorsten and Hashim, Najihah Mohd and Al-Madhagi, Wafa M. and Ali, Hapipah Mohd (2020) Benzimidazolium-acridine-based silver N-heterocyclic carbene complexes as potential anti-bacterial and anti-cancer drug. Inorganica Chimica Acta, 504. p. 119462. ISSN 0020-1693

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Official URL: https://doi.org/10.1016/j.ica.2020.119462

Abstract

A series of N-alkylated benzimidazolium salts based on 9-substituted acridine has been synthesized and subsequently converted into the corresponding Ag(I) carbene complexes. The compounds were characterized by IR, 1H and 13C NMR spectroscopy. Identity and purity were confirmed by HRMS and elemental analysis, respectively. Both, ligands and complexes, were evaluated on their antibacterial and anticancer potential. All complexes exhibited higher activity against both Gram positive and Gram negative bacterial strains than the corresponding ligands. Human cell line experiments indicated low in-vitro cytotoxicity, while some of the complexes showed promising activity against breast cancer cells. © 2020 Elsevier B.V.

Item Type: Article
Uncontrolled Keywords: 9-Aminoacridine; Ag(I)-benzimidazolium; Breast cancer (MCF-7); Gram positive; Gram negative
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine
Faculty of Science > Dept of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 24 Jun 2020 02:35
Last Modified: 24 Jun 2020 02:35
URI: http://eprints.um.edu.my/id/eprint/24962

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