Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients

Nazratun, N.; Mahmood Merican, A.; Kuppusamy, U.R.; Ahmad, T.S.; Tan, S.Y. (2007) Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients. Vascular Medicine, 11 (4). pp. 245-250. ISSN 1358-863X

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    The excess accumulation of advanced glycation end products (AGEs) contributes to the chronic complications of type 2 diabetes mellitus (DM) and renal failure. Biopsy specimens (n = 184) of arterial (n = 92) and venous (n = 92) tissues were obtained (radial artery and cephalic vein) from end-stage renal disease (ESRD) patients with or without DM and normal healthy subjects (n = 12) requiring surgery (trauma patients). Immunohistochemical assessment of the blood vessels revealed the presence of pentosidine (AGE marker) in both veins and arteries in 72% of the ESRD patients. The percentage of arteries and veins that showed positive pentosidine staining in ESRD patients with type 2 DM alone was 100% and 92% respectively, in the non-diabetic ESRD patients it was <70% (for arteries and veins), and in the ESRD patients with hypertension as an additional co-morbidity to type 2 DM it was 70% and 82%, respectively. The veins of ESRD patients with DM showed a strong (+++) positive staining and very strong (++++) positive staining was observed in the patients with DM and hypertension. Only mild (+) or moderate (++) pentosidine staining intensity was observed in the arteries of ESRD patients without or with comorbidities, respectively. The accumulation of AGE in the vein rather than the artery may be a better reflection of the extent of complications of ESRD.

    Item Type: Article
    1. Nazratun, N.
    2. Mahmood Merican, A.
    3. Kuppusamy, U.R.
    4. Ahmad, T.S.
    5. Tan, S.Y.
    Journal or Publication Title: Vascular Medicine
    Additional Information: Address for correspondence: Umah Rani Kuppusamy, Department of Molecular Medicine, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia. Tel: �60 3 79674900; Fax: �60 3 79676600; E-mail: umah@um.edu.my
    Uncontrolled Keywords: AGE; artery; diabetes mellitus; ESRD; pentosidine; vein
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Nor Izzati Ab Razak
    Date Deposited: 25 Jan 2012 11:07
    Last Modified: 27 Oct 2014 14:57
    URI: http://eprints.um.edu.my/id/eprint/2496

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