Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients

Nazratun, N. and Mahmood Merican, A. and Kuppusamy, U.R. and Ahmad, T.S. and Tan, S.Y. (2007) Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients. Vascular Medicine, 11 (4). pp. 245-250. ISSN 1358-863X,

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Abstract

The excess accumulation of advanced glycation end products (AGEs) contributes to the chronic complications of type 2 diabetes mellitus (DM) and renal failure. Biopsy specimens (n = 184) of arterial (n = 92) and venous (n = 92) tissues were obtained (radial artery and cephalic vein) from end-stage renal disease (ESRD) patients with or without DM and normal healthy subjects (n = 12) requiring surgery (trauma patients). Immunohistochemical assessment of the blood vessels revealed the presence of pentosidine (AGE marker) in both veins and arteries in 72% of the ESRD patients. The percentage of arteries and veins that showed positive pentosidine staining in ESRD patients with type 2 DM alone was 100% and 92% respectively, in the non-diabetic ESRD patients it was <70% (for arteries and veins), and in the ESRD patients with hypertension as an additional co-morbidity to type 2 DM it was 70% and 82%, respectively. The veins of ESRD patients with DM showed a strong (+++) positive staining and very strong (++++) positive staining was observed in the patients with DM and hypertension. Only mild (+) or moderate (++) pentosidine staining intensity was observed in the arteries of ESRD patients without or with comorbidities, respectively. The accumulation of AGE in the vein rather than the artery may be a better reflection of the extent of complications of ESRD.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Address for correspondence: Umah Rani Kuppusamy, Department of Molecular Medicine, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia. Tel: �60 3 79674900; Fax: �60 3 79676600; E-mail: umah@um.edu.my
Uncontrolled Keywords:	AGE; artery; diabetes mellitus; ESRD; pentosidine; vein
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Nor Izzati Ab Razak
Date Deposited:	25 Jan 2012 03:07
Last Modified:	27 Oct 2014 06:57
URI:	http://eprints.um.edu.my/id/eprint/2496

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