Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Shu, Xiang and Long, Jirong and Cai, Qiuyin and Kweon, Sun-Seog and Choi, Ji-Yeob and Kubo, Michiaki and Park, Sue K. and Bolla, Manjeet K. and Dennis, Joe and Wang, Qin and Yang, Yaohua and Shi, Jiajun and Guo, Xingyi and Li, Bingshan and Tao, Ran and Aronson, Kristan J. and Chan, Kelvin Y.K. and Chan, Tsun L. and Gao, Yu-Tang and Hartman, Mikael and Kee Ho, Weang and Ito, Hidemi and Iwasaki, Motoki and Iwata, Hiroji and John, Esther M. and Kasuga, Yoshio and Soon Khoo, Ui and Kim, Mi-Kyung and Kong, Sun-Young and Kurian, Allison W. and Kwong, Ava and Lee, Eun-Sook and Li, Jingmei and Lophatananon, Artitaya and Low, Siew-Kee and Mariapun, Shivaani and Matsuda, Koichi and Matsuo, Keitaro and Muir, Kenneth and Noh, Dong-Young and Park, Boyoung and Park, Min-Ho and Shen, Chen-Yang and Shin, Min-Ho and Spinelli, John J. and Takahashi, Atsushi and Tseng, Chiuchen and Tsugane, Shoichiro and Wu, Anna H. and Xiang, Yong-Bing and Yamaji, Taiki and Zheng, Ying and Milne, Roger L. and Dunning, Alison M. and Pharoah, Paul D.P. and García-Closas, Montserrat and Teo, Soo Hwang and Shu, Xiao-ou and Kang, Daehee and Easton, Douglas F. and Simard, Jacques and Zheng, Wei (2020) Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants. Nature Communications, 11 (1). p. 1217. ISSN 2041-1723

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Official URL: https://doi.org/10.1038/s41467-020-15046-w

Abstract

Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10−8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women. © 2020, The Author(s).

Item Type: Article
Uncontrolled Keywords: Breast Neoplasms; Risk; Susceptibility loci
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 23 Jun 2020 07:17
Last Modified: 23 Jun 2020 07:17
URI: http://eprints.um.edu.my/id/eprint/24948

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