Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata

Chung, L.Y.; Yap, K.F.; Mustafa, M.R.; Goh, S.H.; Imiyabir, Z. (2008) Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata. Phytochemistry, 69 (7). pp. 1548-1554. ISSN 0031-9422

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    The bark extract of Melicope subunifoliolata (Stapf) T.G. Hartley showed competitive muscarinic receptor binding activity. Six polymethoxyflavones [melibentin (1);melisimplexin(3);3,30,40,5,7pentamethoxyflavone(4);melite rnatin (5); 3,5,8-trimethoxy-30,40,6,7 bismethylenedioxyflavone (6); and isokanugin (7)] and one furanocoumarin [5-methoxy-8-geranyloxypsoralen (2)]were isolated fromthe bark extract. Compounds 2 and 6 were isolated for the first time from M. subunifoliolata. Themethoxyflavones (compounds 1, 3, 4, 5, 6, and 7) show moderate inhibition in a muscarinic receptor binding assay, while the furanocoumarin (compound 2) is inactive. The potency of the methoxyflavones to inhibit [ 3 H]NMS-muscarinic receptor binding is influenced by the position and number of methoxy substitution. The results suggest these compounds are probably muscarinic modulators, agonists or partial agonists/antagonists.

    Item Type: Article
    1. Chung, L.Y.
    2. Yap, K.F.
    3. Mustafa, M.R.
    4. Goh, S.H.
    5. Imiyabir, Z.
    Journal or Publication Title: Phytochemistry
    Additional Information: Corresponding author. Tel.: +603 79674909; fax: +603 79674964. E-mail addresses:,
    Uncontrolled Keywords: Melicope Subunifoliolata; Rutaceae; Flavonoid; Muscarinic Receptor
    Subjects: Q Science > QD Chemistry
    R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 17 Jan 2012 11:41
    Last Modified: 11 Dec 2014 16:05

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