Antigen specific lymphocyte proliferative response of patients with acute and chronic toxoplasmosis

Khairul Anuar, A. and Rahman, N. and Dighe, V.C. and Nor, Zurainee Mohamed and Suresh, K. and Yano, A. (1999) Antigen specific lymphocyte proliferative response of patients with acute and chronic toxoplasmosis. Journal of the University of Malaya Medical Centre (JUMMEC), 4 (1). pp. 34-38. ISSN 1823-7339

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Official URL: https://jummec.um.edu.my/article/view/4429

Abstract

In vitro lymphocyte proliferative response of peripheral blood Ieucocytes (PBL) to purified Toxoplasma gondii antigen were evaluated by 3[H] methyl thymidine incorporation in patients acutely and chronically infected with Toxoplasma gondii. PBL from three patients with acute symptomatic toxoplasmosis showed no response to T. gondii antigen during the emergence of anti-Toxoplasma IgM antibodies and the response returned as the infection became chronic. Lymphocytes of twelve chronically infected patients responded positively to the antigen. In all patients the lymphocyte proliferative response to the mitogen, Concanavalin A (Con A) was normal. Analysis of Toxoplasma proliferative response of PBL from a patient with acute toxopiasmosis showed that CD8* cells were responsible for induction of suppression while the response during the chronic infection was mediated by CD4* cells. In human toxoplasmosis there was antigen-specific lymphocyte unresponsiveness during the acute phase of the infection and it appears that the immunesuppression was mediated by CD8+ cells.

Item Type: Article
Uncontrolled Keywords: Toxoplasmosis-lymphocyte blastogenesis-antigen specific-CD4+; CD8+
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr Jasny Razali
Date Deposited: 22 Mar 2021 05:25
Last Modified: 22 Mar 2021 05:25
URI: http://eprints.um.edu.my/id/eprint/24511

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