Expression of human b-defensin-3 in oral squamous cell carcinoma using tissue microarray - A preliminary study

Hussaini, H.M.; Lim, P.K.; Rahman, R.A.; Abraham, T.; Cheong, C.S.; Zain, R.B.; Ismail, M.S; Nam, A.N. (2006) Expression of human b-defensin-3 in oral squamous cell carcinoma using tissue microarray - A preliminary study. Journal Of Oral Pathology & Medicine, 35 (7). pp. 432-433. ISSN 0904-2512

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    Abstract

    Purpose: Human b-Defensin (hBDs) is an epithelial origin, cationic antimicrobial peptides. Their expression is reported in oral mucosa, gingiva and salivary glands. However, their protective role is not well understood. It has been suggested that bacterial and viral infection are an important factors in the process of carcinogenesis. This study investigated the expression of hBD-3 in oral squamous cells carcinoma (OSCC). Methods: 29 OSCC and 23 samples of normal and dysplastic tissues were obtained from Oral Pathology diagnostic laboratory, faculty of Dentistry, UKM and UM. The tissues were arrayed and the expression of hBD-3 was analysed using immunohistochemistry technique. Results: Higher levels of hBD-3 expression were found in stage II and II of OSCC compared to stage I and IV. Expression of hBD-3 was also seen higher in the tumour front arrays. Healthy and dysplastic tissues also seen to expressed hBD-3 but most are moderately stained. Conclusion: High levels of hBD-3 expression is seen especially in stage II and III as well as in tumour front suggest a potential tumour marker, correlation between level of expression and probable infective cancer causes need to be investigate further.

    Item Type: Article
    Creators:
    1. Hussaini, H.M.( Univ Malaya, Kuala Lumpur 59100, Malaysia)
    2. Lim, P.K.( Univ Malaya, Kuala Lumpur 59100, Malaysia)
    3. Rahman, R.A.( Univ Malaya, Kuala Lumpur 59100, Malaysia)
    4. Abraham, T.( Univ Malaya, Kuala Lumpur 59100, Malaysia)
    5. Cheong, C.S.( Univ Malaya, Kuala Lumpur 59100, Malaysia)
    6. Zain, R.B.(Department of Oral Pathology and Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya)
    7. Ismail, M.S( Univ Malaya, Kuala Lumpur 59100, Malaysia)
    8. Nam, A.N.( Univ Malaya, Kuala Lumpur 59100, Malaysia)
    Journal or Publication Title: Journal Of Oral Pathology & Medicine
    Additional Information: Prof. Dr. Rosnah Mohd Zain Department of Oral Pathology and Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya
    Uncontrolled Keywords: Oral Squamous Cell Carcinoma, OSCC, Lichenoid Lesions, Lichen Planus, Oral Cancer, Oral Tumours, Pemphigus, Traumatic Eosinophilic Granuloma, Aphthous Ulcers, Oral Mucosal Lesions, Betel Chewers Mucosa, Betel Quid Related Lesions, Betel Quid, Areca Quid, Tobacco Quid, Oral Cancer Screening, Training and Calibration, Early Detection, Oral Cancer Awareness, Biobanking, Tissue Bank, Databank, Oral Cancer, Tissue Bank, Research Credibility, Research Ethics.
    Subjects: R Medicine
    R Medicine > RK Dentistry
    R Medicine > RK Dentistry > Oral surger
    Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
    Depositing User: Prof. Dr. Rosnah Mohd Zain
    Date Deposited: 17 Jan 2012 09:21
    Last Modified: 11 Dec 2013 15:29
    URI: http://eprints.um.edu.my/id/eprint/2445

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