Liew, S. Y.; Mukhtar, M.R.; Awang, K.; Mustafa, M R; Ng, S.W. (2011) 1-(1-Hydroxyethyl)-7, 8-dihydroindolo [2, 3-a] pyridine [3, 4-g] quinolizin-5 (13H)-one (angustoline) monohydrate from Nauclea subdita (Rubiaceae). Acta Crystallographica Section E: Structure Reports Online, 67 (7). o1727-o1728. ISSN 1600-5368
The title compound (trivial name: angustoline monohydrate), C20H17N3O2 H2O, features a fused-ring system formed by one ﬁve- and four six-membered rings. The nearly planar benzimidazole portion (r.m.s. deviation = 0.008 A˚) and the nearly planar 2,7-naphthyridin-1-one portion (r.m.s. deviation = 0.022 A˚) of the fused-ring system are slightly twisted, with a dihedral angle of 9.47 (8), owing to the tetrahedral nature of the two methylene linkages in the central six-membered ring. The secondary N atom acts as a hydrogen-bond donor to the water molecule of crystallization. In the crystal, the amino and hydroxy groups, and the water molecule are engaged in hydrogen bonding, generating a three-dimensional network.
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