Liew, Sook Yee and Mukhtar, Mat Ropi and Awang, Khalijah and Mustafa, Mohd Rais and Ng, Seik Weng (2011) 1-(1-Hydroxyethyl)-7, 8-dihydroindolo [2, 3-a] pyridine [3, 4-g] quinolizin-5 (13H)-one (angustoline) monohydrate from Nauclea subdita (Rubiaceae). Acta Crystallographica Section E: Structure Reports Online, 67 (7). o1727-o1728. ISSN 1600-5368, DOI https://doi.org/10.1107/S1600536811022768.
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1-(1-Hydroxyethyl)-7,_8-dihydroindolo_[2,_3-a]_pyridine_[3,_4-g]_quinolizin-5_(13H)-one_(angustoline)_monohydrate_from_Nauclea_subdita_(Rubiaceae).pdf - Published Version Download (449kB) |
Abstract
The title compound (trivial name: angustoline monohydrate), C20H17N3O2 H2O, features a fused-ring system formed by one five- and four six-membered rings. The nearly planar benzimidazole portion (r.m.s. deviation = 0.008 A˚) and the nearly planar 2,7-naphthyridin-1-one portion (r.m.s. deviation = 0.022 A˚) of the fused-ring system are slightly twisted, with a dihedral angle of 9.47 (8), owing to the tetrahedral nature of the two methylene linkages in the central six-membered ring. The secondary N atom acts as a hydrogen-bond donor to the water molecule of crystallization. In the crystal, the amino and hydroxy groups, and the water molecule are engaged in hydrogen bonding, generating a three-dimensional network.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia, and Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia Correspondence e-mail: seikweng@um.edu.my |
| Uncontrolled Keywords: | Single-crystal X-ray Study; T = 100 K; Mean �(C–C) = 0.003 A˚; R Factor = 0.036; wR factor = 0.098; Data-to-parameter Ratio = 13.0. |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms Haslinda Lahuddin |
| Date Deposited: | 16 Jan 2012 02:45 |
| Last Modified: | 18 Dec 2019 06:36 |
| URI: | http://eprints.um.edu.my/id/eprint/2430 |
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