Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta

Ajay, M.; Mustafa, M.R. (2005) Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. Journal of Cardiovascular Pharmacology and Therapeutics, 46 (1). pp. 36-40.

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    Abstract

    Flavonoids are known to possess cardioprotective properties. Vascular endothelial function is a surrogate marker for cardiovascular diseases, including hypertension. We have studied the effects of chronic flavonoid treatment on vascular endothelial functions in spontaneously hypertensive rats (SHR). Starting from 6–7 weeks old, SHR were given flavonoids (baicalein, flavone, or quercetin) orally (10 mg/kg, once daily) to the SHRs for 4 weeks. Aortas from all the flavonoid-treated animals showed remarkably higher endothelium-dependent relaxations to acetylcholine, to a similar extent as those pretreated with the angiotensin-converting enzyme inhibitor, captopril. However, in contrast to other experimental groups, flavone pretreatment also enhanced the endotheliumindependent relaxations to sodium nitroprusside. In addition, treatment with either flavone or quercetin induced a significant attenuation in systolic blood pressure of the hypertensive animals. The present results suggest that chronic treatment with the flavonoids (baicalein, flavone, and quercetin) preserves vascular endothelial functions in hypertensive animals through several possible actions, including increasing endothelial nitric oxide production and bioavailability and reduction in blood pressure.

    Item Type: Article
    Creators:
    1. Ajay, M.
    2. Mustafa, M.R.
    Journal or Publication Title: Journal of Cardiovascular Pharmacology and Therapeutics
    Additional Information: Reprints: Mohd Rais Mustafa, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia (e-mail: rais@um.edu.my).
    Uncontrolled Keywords: Hypertension, Vascular Endothelium, Nitric Oxide, Blood Pressure, Flavonoids
    Subjects: R Medicine > RM Therapeutics. Pharmacology
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 13 Jan 2012 11:38
    Last Modified: 13 Jan 2012 11:38
    URI: http://eprints.um.edu.my/id/eprint/2421

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