Ajay, M.; Mustafa, M.R. (2005) Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. Journal of Cardiovascular Pharmacology and Therapeutics, 46 (1). pp. 36-40.
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Flavonoids are known to possess cardioprotective properties. Vascular endothelial function is a surrogate marker for cardiovascular diseases, including hypertension. We have studied the effects of chronic ﬂavonoid treatment on vascular endothelial functions in spontaneously hypertensive rats (SHR). Starting from 6–7 weeks old, SHR were given ﬂavonoids (baicalein, ﬂavone, or quercetin) orally (10 mg/kg, once daily) to the SHRs for 4 weeks. Aortas from all the ﬂavonoid-treated animals showed remarkably higher endothelium-dependent relaxations to acetylcholine, to a similar extent as those pretreated with the angiotensin-converting enzyme inhibitor, captopril. However, in contrast to other experimental groups, ﬂavone pretreatment also enhanced the endotheliumindependent relaxations to sodium nitroprusside. In addition, treatment with either ﬂavone or quercetin induced a signiﬁcant attenuation in systolic blood pressure of the hypertensive animals. The present results suggest that chronic treatment with the ﬂavonoids (baicalein, ﬂavone, and quercetin) preserves vascular endothelial functions in hypertensive animals through several possible actions, including increasing endothelial nitric oxide production and bioavailability and reduction in blood pressure.
|Journal or Publication Title:||Journal of Cardiovascular Pharmacology and Therapeutics|
|Additional Information:||Reprints: Mohd Rais Mustafa, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia (e-mail: firstname.lastname@example.org).|
|Uncontrolled Keywords:||Hypertension, Vascular Endothelium, Nitric Oxide, Blood Pressure, Flavonoids|
|Subjects:||R Medicine > RM Therapeutics. Pharmacology|
|Divisions:||Faculty of Medicine|
|Depositing User:||Ms Haslinda Lahuddin|
|Date Deposited:||13 Jan 2012 11:38|
|Last Modified:||13 Jan 2012 11:38|
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