Kamaruzman, Nur Izyani and Aziz, Noraini Abd and Poh, Chit Laa and Chowdhury, Ezharul Hoque (2019) Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer. Cancers, 11 (5). p. 632. ISSN 2072-6694, DOI https://doi.org/10.3390/cancers11050632.
Full text not available from this repository.Abstract
Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling cascades with other intracellular pathways in breast cancer could lead to massive abnormal signaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles in cancer development would give a promising therapeutics strategy in combating the disease. Genetic manipulations through siRNAs targeting the complementary sequence of the oncogenic mRNA in breast cancer is one of the promising approaches that can be harnessed to develop more efficient treatments for breast cancer. In this review, we highlighted the effects of major signaling pathways stimulated by oncogene products on breast tumorigenesis and discussed the potential therapeutic strategies for targeted delivery of siRNAs with nanoparticles in suppressing the stimulated signaling pathways. © 2019, MDPI AG. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | Sunway University Research Centre Grant (2018) |
| Uncontrolled Keywords: | breast cancer; siRNA; cell signaling; active targeting; passive targeting; EPR effect; oncogenes; nanoparticles; nanomedicine |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 Apr 2020 05:53 |
| Last Modified: | 08 Apr 2020 05:53 |
| URI: | http://eprints.um.edu.my/id/eprint/24175 |
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