Long‐term loss to follow‐up in the TREAT Asia HIV Observational Database ( TAHOD )

Jiamsakul, Awachana and Kiertiburanakul, Sasisopin and Ng, Oon Tek and Chaiwarith, Romanee and Wong, W. and Ditangco, R. and Nguyen, K.V. and Avihingsanon, A. and Pujari, S. and Do, C.D. and Lee, M.P. and Ly, P.S. and Yunihastuti, E. and Kumarasamy, N. and Kamarulzaman, Adeeba and Tanuma, J. and Zhang, F. and Choi, J.Y. and Kantipong, P. and Sim, B.L.H. and Ross, J. and Law, M. and Merati, T.P. and Ly, P.S. and Khol, V. and Zhang, F.J. and Zhao, H.X. and Han, N. and Lee, M.P. and Li, P.C.K. and Lam, W. and Chan, Y.T. and Kumarasamy, N. and Saghayam, S. and Ezhilarasi, C. and Pujari, S. and Joshi, K. and Gaikwad, S. and Chitalikar, A. and Sangle, S. and Mave, V. and Marbaniang, I. and Merati, T. P. and Wirawan, D. N. and Yuliana, F. and Yunihastuti, E. and Imran, D. and Widhani, A. and Tanuma, J. and Oka, S. and Nishijima, T. and Choi, J. Y. and Na, S. and Kim, J. M. and Sim, B.L.H. and Gani, Y.M. and Rudi, N.B. and Kamarulzaman, A. and Syed Omar, S.F. and Ponnampalavanar, S. and Azwa, I. and Ditangco, R. and Pasayan, M.K. and Mationg, M.L. and Wong, W.W. and Ku, W.W. and Wu, P.C. and Ng, O.T. and Lim, P.L. and Lee, L.S. and Ferdous, Z. and vihingsanon, A. and Gatechompol, S. and Phanuphak, P. and Phadungphon, C. and Kiertiburanakul, S. and Phuphuakrat, A. and Chumla, L. and Sanmeema, N. and Chaiwarith, R. and Sirisanthana, T. and Kotarathititum, W. and Praparattanapan, J. and Khusuwan, S. and Nguyen, K.V. and Bui, H.V. and Nguyen, D.T.H. and Nguyen, D.T. and Do, C.D. and Ngo, A.V. and Nguyen, L.T. and Sohn, A.H. and Ross, L. and Petersen, B. and Law, M.G. and Jiamsakul, A. and Rupasinghe, D. (2019) Long‐term loss to follow‐up in the TREAT Asia HIV Observational Database ( TAHOD ). HIV Medicine, 20 (7). pp. 439-449. ISSN 1464-2662

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Official URL: https://doi.org/10.1111/hiv.12734

Abstract

Objectives: With earlier antiretroviral therapy (ART) initiation, time spent in HIV care is expected to increase. We aimed to investigate loss to follow-up (LTFU) in Asian patients who remained in care 5 years after ART initiation. Methods: Long-term LTFU was defined as LTFU occurring after 5 years on ART. LTFU was defined as (1) patients not seen in the previous 12 months; and (2) patients not seen in the previous 6 months. Factors associated with LTFU were analysed using competing risk regression. Results: Under the 12-month definition, the LTFU rate was 2.0 per 100 person-years (PY) [95% confidence interval (CI) 1.8–2.2 among 4889 patients included in the study. LTFU was associated with age > 50 years [sub-hazard ratio (SHR) 1.64; 95% CI 1.17–2.31] compared with 31–40 years, viral load ≥ 1000 copies/mL (SHR 1.86; 95% CI 1.16–2.97) compared with viral load < 1000 copies/mL, and hepatitis C coinfection (SHR 1.48; 95% CI 1.06–2.05). LTFU was less likely to occur in females, in individuals with higher CD4 counts, in those with self-reported adherence ≥ 95%, and in those living in high-income countries. The 6-month LTFU definition produced an incidence rate of 3.2 per 100 PY (95% CI 2.9–3.4 and had similar associations but with greater risks of LTFU for ART initiation in later years (2006–2009: SHR 2.38; 95% CI 1.93–2.94; and 2010–2011: SHR 4.26; 95% CI 3.17–5.73) compared with 2003–2005. Conclusions: The long-term LTFU rate in our cohort was low, with older age being associated with LTFU. The increased risk of LTFU with later years of ART initiation in the 6-month analysis, but not the 12-month analysis, implies that there was a possible move towards longer HIV clinic scheduling in Asia. © 2019 British HIV Association

Item Type: Article
Uncontrolled Keywords: Asia; HIV; long term; lost to follow-up
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 06 Apr 2020 07:09
Last Modified: 06 Apr 2020 07:09
URI: http://eprints.um.edu.my/id/eprint/24142

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