Jayapalan, Ronie Romelean and Mun, Kein Seong and Wong, Kum Thong and Sia, Sheau Fung (2019) Malignant Transformation of a Rosette-Forming Glioneuronal Tumor with IDH1 Mutation: A Case Report and Literature Review. World Neurosurgery: X, 2. p. 100006. ISSN 2590-1397, DOI https://doi.org/10.1016/j.wnsx.2018.100006.
Full text not available from this repository.Abstract
Background: Rosette-forming glioneuronal tumor (World Health Organization grade I) is considered as a benign tumor with very low potential for progression. The potential for malignant transformation of this tumor is not known and has never been reported before in literature. Case Description: We report a 42-year-old man, diagnosed with rosette-forming glioneuronal tumor of the fourth ventricle with a positive isocitrate dehydrogenase 1 mutation, progressed to glioblastoma after 6 years from diagnosis. We discuss the clinical history, radiological findings, and histopathological characteristic with immunohistochemistry findings observed in this unique case. Conclusions: Despite being acceptable as benign, based on our observations in this case, there is a potential for malignant transformation of rosette-forming glioneuronal tumor. The role of isocitrate dehydrogenase 1 mutation leading to malignant transformation could not be established as our finding is novel and further prospective studies are required to prove this association. © 2019 The Author(s)
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Glioblastoma IDH mutant; IDH 1 mutation; Malignant transformation; RGNT |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Apr 2020 05:39 |
| Last Modified: | 03 Apr 2020 05:39 |
| URI: | http://eprints.um.edu.my/id/eprint/24137 |
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