A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules

Ito, Terushi and Okada, Kotaro and Leong, Kok Hoong and Hirai, Daijiro and Hayashi, Yoshihiro and Kumada, Shungo and Kosugi, Atsushi and Onuki, Yoshinori (2019) A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules. Chemical and Pharmaceutical Bulletin, 67 (3). pp. 271-276. ISSN 0009-2363

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Official URL: https://doi.org/10.1248/cpb.c18-00888

Abstract

The different states of water incorporated in wet granules were studied by a low-field benchtop 1H-NMR time-domain NMR (TD-NMR) instrument. Wet granules consisting different fillers [cornstarch (CS), microcrystalline cellulose (MCC), and D-mannitol (MAN)] with different water contents were prepared using a high-speed granulator, and then their spin–spin relaxation time (T2) was measured using the NMR relaxation technique. The experimental T2 relaxation curves were analyzed by the two-component curve fitting, and then the individual T2 relaxation behaviors of solid and water in wet granules were identified. According to the observed T2 values, it was confirmed that the molecular mobility of water in CS and MCC granules was more restricted than that in the MAN granule. The state of water appeared to be associated with the drying efficiency and moisture absorption capacity of wet granules. Thus, it was confirmed that the state of water significantly affected the wet granulation process and the characteristics of the resultant granules. In the final phase of this study, the effects of binders on the molecular mobility of water in granulation fluids and wet granules were examined. The state of water in granulation fluids was substantially changed by changing the binders. The difference was still detected in wet granules prepared by addition of these fluids to the fillers. In conclusion, TD-NMR can offer valuable knowledge on wet granulation from the viewpoint of molecular mobility of water. © 2019 The Pharmaceutical Society of Japan.

Item Type: Article
Uncontrolled Keywords: time-domain NMR; wet granulation; state of water; spin–spin relaxation time (T2); filler; binder
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 26 Mar 2020 04:43
Last Modified: 26 Mar 2020 04:43
URI: http://eprints.um.edu.my/id/eprint/24102

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