In Vitro and In Vivo Anti-Inflammatory Activity of 17-O-Acetylacuminolide through the Inhibition of Cytokines, NF-κB Translocation and IKKβ Activity

Achoui, M.; David , A.; Abdullah, M.A.; Awang, K.; Mohd, M.A.; Mustafa, M.R. (2010) In Vitro and In Vivo Anti-Inflammatory Activity of 17-O-Acetylacuminolide through the Inhibition of Cytokines, NF-κB Translocation and IKKβ Activity. PLoS One, 5 (12). e15105. ISSN 1932-6203

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Abstract

Objectiw: The main purpose of this paper is to present a new method of predicting clinical performance using mechanical loading in a ball mill. Methods: A series of four experiments (two involving a hybrid composite and one each on orthodontic brackets and bands) is described in which the ball mill was used to subject specimens to mechanical fatigue. Results: A reproducibility study using composite beam specimens showed no significant difference between the Mean Survival Time (MST) in all the three experimental runs (P = 0.42). When subjected to thermal cycling, the MST of the cycled group was 155.0 min compared to 247.0 min for the control group(P < 0.01). The MST of untreated and sandblasted brackets was 7.9 h and 14 h respectively (P < 0.01). There is also a significant difference (P < 0.001) in the MST of sandblasted bands when compared to the untreated bands. Conclusions: The ball mill proved to be a convenient and reproducible means of producing mechanical fatigue and may be useful in predicting the clinical performance of dental materia

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