Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition

Abdelwahab, S.I.; Mohamed, A.H.; Oall, M.; Mohamed, O.Y.; Elhassan Taha, M.M.; Mohan, S.; Noordin, M.I.; Mustafa, M.R.; M. Alkharfy, K. (2011) Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition. Evidence-based complementary and alternative medicine: eCAM, 2012. p. 137386. ISSN 1741-427X

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    Abstract

    Clerodendron capitatum (Willd) (family: verbenaceae) is locally named as Gung and used traditionally to treat erectile dysfunction.Therefore, the current study was designed to investigate the erectogenic properties of C. capitatum. The relaxation effect of this plant was tested on phenylephrine precontracted rabbit corpus cavernosum smooth muscle (CCSM). The effects of C. capitatum were also examined on isolated Guinea pig atria alone, in the presence of calcium chloride (Ca 2+ channel blocker), atropine(cholinergic blocker), and glibenclamide (ATP-sensitive K +channel blocker). These effects were confirmed on isolated rabbit aortic strips. The extract, when tested colorimetrically for its inhibitory activities on phosphordiesterase-5 (PDE-5) in vitro towards pnitrophenyl phenyl phosphate (PNPPP), was observed to induce significant dose-dependent inhibition of PDE-5, with an ID50 of 0.161 mg/ml (P < .05). In conclusion, our results suggest that C. capitatum possesses a relaxant effect on CCSM, which is attributable to the inhibition of PDE-5, but not mediated by the release calcium, activation of adrenergic or cholinergic receptors, or the activation of potassium channels.

    Item Type: Article
    Creators:
    1. Abdelwahab, S.I.(University of Malaya)
    2. Mohamed, A.H.
    3. Oall, M.
    4. Mohamed, O.Y.
    5. Elhassan Taha, M.M.
    6. Mohan, S.(University of Malaya)
    7. Noordin, M.I.(University of Malaya)
    8. Mustafa, M.R.(University of Malaya)
    9. M. Alkharfy, K.
    Journal or Publication Title: Evidence-based complementary and alternative medicine: eCAM
    Additional Information: Correspondence should be addressed to Siddig Ibrahim Abdelwahab, siddigroa@yahoo.com
    Uncontrolled Keywords: Clerodendron Capitatum
    Subjects: R Medicine > R Medicine (General)
    R Medicine > RM Therapeutics. Pharmacology
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 09 Jan 2012 10:57
    Last Modified: 09 Jan 2012 10:57
    URI: http://eprints.um.edu.my/id/eprint/2406

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