Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition

Abdelwahab, S.I. and Mohamed, A.H. and Oall, M. and Mohamed, O.Y. and Elhassan Taha, M.M. and Mohan, S. and Noordin, M.I. and Mustafa, Mohd Rais and M. Alkharfy, K. (2011) Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition. Evidence-Based Complementary and Alternative Medicine, 2012. p. 137386. ISSN 1741-427X, DOI https://doi.org/10.1155/2012/137386.

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Official URL: https://doi.org/10.1155/2012/137386

Abstract

Clerodendron capitatum (Willd) (family: verbenaceae) is locally named as Gung and used traditionally to treat erectile dysfunction.Therefore, the current study was designed to investigate the erectogenic properties of C. capitatum. The relaxation effect of this plant was tested on phenylephrine precontracted rabbit corpus cavernosum smooth muscle (CCSM). The effects of C. capitatum were also examined on isolated Guinea pig atria alone, in the presence of calcium chloride (Ca 2+ channel blocker), atropine(cholinergic blocker), and glibenclamide (ATP-sensitive K +channel blocker). These effects were confirmed on isolated rabbit aortic strips. The extract, when tested colorimetrically for its inhibitory activities on phosphordiesterase-5 (PDE-5) in vitro towards pnitrophenyl phenyl phosphate (PNPPP), was observed to induce significant dose-dependent inhibition of PDE-5, with an ID50 of 0.161 mg/ml (P < .05). In conclusion, our results suggest that C. capitatum possesses a relaxant effect on CCSM, which is attributable to the inhibition of PDE-5, but not mediated by the release calcium, activation of adrenergic or cholinergic receptors, or the activation of potassium channels.

Item Type: Article
Funders: UNSPECIFIED
Additional Information: Correspondence should be addressed to Siddig Ibrahim Abdelwahab, siddigroa@yahoo.com
Uncontrolled Keywords: Clerodendron Capitatum
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 09 Jan 2012 02:57
Last Modified: 29 Jan 2020 06:53
URI: http://eprints.um.edu.my/id/eprint/2406

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