Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies

Muhammad, Akhtar and Khan, Behramand and Iqbal, Zafar and Khan, Amir Zada and Khan, Inamullah and Khan, Kashif and Alamzeb, Muhammad and Ahmad, Nasir and Khan, Khalid and Lal Badshah, Syed and Ullah, Asad and Muhammad, Sayyar and Jan, Muhammad Tariq and Nadeem, Said and Kabir, Nurul (2019) Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies. ACS Omega, 4 (10). pp. 14188-14192. ISSN 2470-1343

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Official URL: https://doi.org/10.1021/acsomega.9b01041

Abstract

The antipyretic potential of viscosine, a natural product isolated from the medicinal plant Dodonaea viscosa, was investigated using yeast-induced pyrexia rat model, and its structure-activity relationship was investigated through molecular docking analyses with the target enzymes cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1). The in vivo antipyretic experiments showed a progressive dose-dependent reduction in body temperatures of the hyperthermic test animals when injected with viscosine. Comparison of docking analyses with target enzymes showed strongest bonding interactions (binding energy -17.34 kcal/mol) of viscosine with the active-site pocket of mPGES-1. These findings suggest that viscosine shows antipyretic properties by reducing the concentration of prostaglandin E2 in brain through its mPGES-1 inhibitory action and make it a potential lead compound for developing effective and safer antipyretic drugs for treating fever and related pathological conditions. Copyright © 2019 American Chemical Society.

Item Type: Article
Uncontrolled Keywords: Dinoprostone; Prostaglandins E; MPGES-1 inhibitors
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QH Natural history
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 04 Mar 2020 02:22
Last Modified: 04 Mar 2020 02:22
URI: http://eprints.um.edu.my/id/eprint/23951

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