Ab Mumin, Nazimah and Rahmat, Kartini and Fadzli, Farhana and Ramli, Marlina Tanty and Westerhout, Caroline Judy and Ramli, Norlisah and Rozalli, Faizatul Izza and Ng, Kwan Hoong (2019) Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population. Scientific Reports, 9 (1). p. 1459. ISSN 2045-2322, DOI https://doi.org/10.1038/s41598-018-37451-4.
Full text not available from this repository.Abstract
Synthesized 2D images can be reconstructed from tomosynthesis images in breast imaging. This study aims to investigate the diagnostic efficacy of synthesized 2D images (C-View) in comparison to full field digital mammography (FFDM) when used with digital breast tomosynthesis (DBT) in multi-ethnic Malaysian population. FFDM and C-View images (n = 380) were independently evaluated by three readers through Breast Imaging Reporting and Data System (BI-RADS) categorisation, breast density and lesion characterisation. Statistical analysis was done comparing sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of C-View + DBT with FFDM + DBT as standard of reference. Very good interreader agreement in BI-RADS category and density assessment between C-View + DBT and FFDM + DBT, with high sensitivity, specificity, PPV and NPV of C-View + DBT when compared with FFDM + DBT. There was comparable PPV between C-View + DBT and FFDM + DBT, with histopathology as gold standard. High level of interreader agreement in BI-RADS category and density assessment for FFDM + DBT and C-View + DBT. There was good agreement between FFDM + DBT and C-View + DBT in mass characterization, and almost perfect agreement in calcification and asymmetric density. 52.2% lower radiation dose incurred when using C-View + DBT. Hence, synthesized 2D images are comparable to FFDM with reduction in radiation dose within the limits of Malaysian multi-ethnic population. © 2019, The Author(s).
| Item Type: | Article |
|---|---|
| Funders: | University Malaya Postgraduate Research Fund (PPP: PO 035-2015 A, RP052B-17HTM and BKP: 052-2017 and 006-2018) |
| Uncontrolled Keywords: | Breast; Mammography; DBT images |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Mar 2020 08:14 |
| Last Modified: | 26 Jul 2021 02:45 |
| URI: | http://eprints.um.edu.my/id/eprint/23939 |
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