Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells And NIH/3T3 Cells

Noor, Nur Affira Mohd and Nafiah, Mohd Azlan and Tuan Johari, Syed Ahmad Tajudin and Hasnan, Muhammad Hafiz Husna and Tan, Siow Ping and Liew, Sook Yee and Supratman, Unang (2019) Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells And NIH/3T3 Cells. International Journal of Recent Technology and Engineering, 8 (2S7). pp. 106-110. ISSN 2277-3878, DOI https://doi.org/10.35940/ijrte.B1024.0782S719.

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Official URL: https://doi.org/10.35940/ijrte.B1024.0782S719

Abstract

Phyllanthus amarus which is locally known as Dukung Anak was one of the herb used in traditional medicine and research of P. amarus in Malaysia was not widely reported. This present research has isolated three chemical compounds and its anticancer effect of this species has been determined. Three lignans namely hypophyllanthin was afforded from hexane crude while niranthin and lintetralin were afforded from ethanol crude. Anticancer test against HeLa cells and NIH/3T3 cells by MTT assays was tested for its anticancer effect. The result shows that hypophyllanthin was considered to possess an active anticancer effect on HeLa cells than NIH/3T3 cells compared to niranthin and lintetralin. © BEIESP.

Item Type: Article
Funders: UNSPECIFIED
Uncontrolled Keywords: Anticancer; HeLa cells; Lignans; NIH/3T3 cells and Phyllanthus amarus
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Centre for Foundation Studies in Science > Chemistry Division
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 18 Feb 2020 01:54
Last Modified: 18 Feb 2020 01:54
URI: http://eprints.um.edu.my/id/eprint/23821

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