A severe form of M-protein negative distal acquired demyelinating symmetric neuropathy

Ong, Tien Lee and Goh, Khean Jin and Shahrizaila, Nortina and Wong, Kum Thong and Tan, Cheng Yin (2019) A severe form of M-protein negative distal acquired demyelinating symmetric neuropathy. Neurology India, 67 (6). pp. 1532-1535. ISSN 0028-3886

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Official URL: https://doi.org/10.4103/0028-3886.273621


Distal acquired demyelinating symmetric neuropathy (DADS) is a variant of chronic inflammatory demyelinating polyneuropathy (CIDP) characterized by symmetrical, distal, sensory or sensorimotor involvement. DADS with M-protein (DADS-M) is less responsive to immunotherapy compared to those without M-protein (DADS-I). We report a case of DADS-I with severe clinical presentation viz. early hand involvement with marked wasting, inexcitable peripheral nerves on neurophysiology and poor response to immunotherapy. Despite the unusual presentation, ancillary tests including cerebrospinal fluid analysis, nerve biopsy and nerve ultrasound were supportive of an inflammatory demyelinating polyneuropathy. This case demonstrated the heterogeneity of the disorder and expands the clinical spectrum of DADS neuropathy. © 2019 Neurology India, Neurological Society of India.

Item Type: Article
Uncontrolled Keywords: Anti-myelin associated glycoprotein neuropathy; chronic inflammatory demyelinating polyneuropathy; distal acquired demyelinating symmetric neuropathy; nerve ultrasound; paraproteinemic neuropathy
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 14 Feb 2020 03:04
Last Modified: 14 Feb 2020 03:04
URI: http://eprints.um.edu.my/id/eprint/23797

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