The association between CKD-associated pruritus and quality of life in patients undergoing hemodialysis in Pakistan

Rehman, Inayat Ur and Chan, Kok Gan and Munib, Syed and Lee, Learn Han and Khan, Tahir Mehmood (2019) The association between CKD-associated pruritus and quality of life in patients undergoing hemodialysis in Pakistan. Medicine, 98 (36). e16812. ISSN 0025-7974

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Official URL: https://doi.org/10.1097/MD.0000000000016812

Abstract

Chronic kidney disease (CKD)-associated pruritus is one of the most common symptoms found in patients who undergo dialysis for CKD, leading to a compromised quality of life. This study aimed to investigate the association between CKD-associated pruritus and the quality of life in patients undergoing hemodialysis in Pakistan. A cross-sectional multicenter study was carried out from July 2016 to April 2017 in 2 tertiary care hospitals in Pakistan. Patients aged 18 years and above of both genders, undergoing hemodialysis, understood the Urdu language, and were willing to participate; were included. Of 354 recruited patients with a response rate of 100%, majority (66.1%) of the patients were males. The median (intra-quartile range [IQR]) age of patients was 42.0 [34.0-50.0] years. The prevalence of pruritus was 74%. The median [IQR] score for pruritus was 10.0 (out of possible 25) [8.0-12.0]. Multivariate linear regression revealed a statistically significant association between CKD-associated pruritus with age of patients (β=0.031; 95% confidence interval [CI]=0.002-0.061; P=.038), duration of CKD (β=-0.013; 95% CI=-0.023 - 0.003; P=.014) and quality of life (β= -0.949; 95% CI=-1.450; -0.449). The median [IQR] score for health-related quality of life was 52.00 [43.00-58.00].Prevalence of CKD-associated pruritus was reported to be 74% and it negatively affected the patient's quality of life. Patients with moderate to severe CKD-associated pruritus have poor quality of life. With an increase in intensity of pruritus, the QOL score decreased among the patients undergoing hemodialysis. Copyright © 2019 the Author(s).

Item Type: Article
Uncontrolled Keywords: CKD-associated pruritus; FANLTC; hemodialysis; Pakistan; quality of life
Subjects: Q Science > QH Natural history
R Medicine
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 03 Feb 2020 04:10
Last Modified: 03 Feb 2020 04:10
URI: http://eprints.um.edu.my/id/eprint/23654

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