Rizwan, Muhammad and Yahya, Rosiyah and Hassan, Aziz and Yar, Muhammad and Abd Halim, Adyani Azizah and Al-Maleki, Anis Rageh and Shahzadi, Lubna and Zubairi, Waliya (2019) Novel chitosan derivative based composite scaffolds with enhanced angiogenesis; potential candidates for healing chronic non-healing wounds. Journal of Materials Science: Materials in Medicine, 30 (6). p. 72. ISSN 0957-4530, DOI https://doi.org/10.1007/s10856-019-6273-3.
Full text not available from this repository.Abstract
The success of wound healing depends upon the proper growth of vascular system in time in the damaged tissues. Poor blood supply to wounded tissues or tissue engineered grafts leads to the failure of wound healing or rejection of grafts. In present paper, we report the synthesis of novel organosoluble and pro-angiogenic chitosan derivative (CSD) by the reaction of chitosan with 1,3-dimethylbarbituric acid and triethylorthoformate (TEOF). The synthesized material was characterized by FTIR and 13C-NMR to confirm the incorporated functional groups and new covalent connectivities. Biodegradability of the synthesized chitosan derivative was tested in the presence of lysozyme and was found to be comparable with CS. The cytotoxicity and apoptosis effect of new derivative was determined against gastric adenocarcinoma (AGS) cells and was found to be non-toxic. The CSD was found to be soluble in majority of organic solvents. It was blended with polycaprolactone (PCL) to form composite scaffolds. From an ex ovo CAM assay, it was noted that CSD stimulated the angiogenesis. [Figure not available: see fulltext.]. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
| Item Type: | Article |
|---|---|
| Funders: | Financial grants from Universiti Malaya (PG335-2016A), Ministry of Higher Education, Malaysia (FP052-2016) |
| Uncontrolled Keywords: | Biodegradability; Cardiovascular system; Cell death; Histology; Tissue |
| Subjects: | Q Science > QD Chemistry R Medicine |
| Divisions: | Faculty of Dentistry Faculty of Medicine Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Feb 2020 03:06 |
| Last Modified: | 03 Feb 2020 03:06 |
| URI: | http://eprints.um.edu.my/id/eprint/23644 |
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