Aggressive, multifocal oral verrucous leukoplakia: Proliferative verrucous leukoplakia or not?

Zain , R.B.; Ghazali, N.; Bakri, M.M. (2003) Aggressive, multifocal oral verrucous leukoplakia: Proliferative verrucous leukoplakia or not? Journal of Oral Pathology and Medicine, 32 (7). pp. 383-392. ISSN 0904-2512

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    Abstract

    Background: Some oral verrucal lesions may constitute parts of the clinicopathological spectrum of proliferative verrucous leukoplakia (PVL). Because of its idiopathic yet sinister nature, it is possible that PVL may exist in other populations. The aim of this study was to review the clinicopathological features of persistent, multifocal, oral verrucal lesions in Malaysian population. Methods: Patients with multifocal oral verrucal lesions were selected from surgical and histopathological records. Results: Nine patients of diverse ethnicity with 43 biopsies were reviewed. The mean age at the presentation was 62 years. The most frequent sites affected were gum, sulci, cheek and tongue. Indulgence in risk habits was reported in about 70% of patients. Four cases developed multifocal carcinoma from multifocal leukoplakia. Conclusions: In retrospect, none of the cases fulfilled the original PVL criteria, although three cases were suggestive of PVL. Nevertheless, these findings do not necessarily preclude the existence of PVL as a clinicopathological entity in Malaysian population.

    Item Type: Article
    Creators:
    1. Zain , R.B.(Dept. Oral Pathol., Oral Med./P., Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia)
    2. Ghazali, N.(Dept. of Oral/Maxillofacial Surgery, Faculty of Dentistry, University of Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia)
    3. Bakri, M.M.(Department of Oral Biology, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia)
    Journal or Publication Title: Journal of Oral Pathology and Medicine
    Additional Information: Ghazali N, Bakri MM, Zain RB. Aggressive, multifocal oral verrucous leukoplakia: proliferative verrucous leukoplakia or not? Journal of Oral Pathology & Medicine. 2003 Aug;32(7):383-92.
    Uncontrolled Keywords: Squamous-cell Carcinoma; Hyperplasia; Lesions; Cavity; Carcinogenesis; Management; Cancers; Mucosa; Tumors
    Subjects: R Medicine
    R Medicine > RB Pathology
    R Medicine > RK Dentistry
    Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
    Depositing User: Prof. Dr. Rosnah Mohd Zain
    Date Deposited: 10 Jan 2012 10:02
    Last Modified: 11 Dec 2013 10:00
    URI: http://eprints.um.edu.my/id/eprint/2364

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