Aggressive, multifocal oral verrucous leukoplakia: Proliferative verrucous leukoplakia or not?

Zain, R.B. and Ghazali, N. and Bakri, M.M. (2003) Aggressive, multifocal oral verrucous leukoplakia: Proliferative verrucous leukoplakia or not? Journal of Oral Pathology and Medicine, 32 (7). pp. 383-392. ISSN 0904-2512

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Abstract

Background: Some oral verrucal lesions may constitute parts of the clinicopathological spectrum of proliferative verrucous leukoplakia (PVL). Because of its idiopathic yet sinister nature, it is possible that PVL may exist in other populations. The aim of this study was to review the clinicopathological features of persistent, multifocal, oral verrucal lesions in Malaysian population. Methods: Patients with multifocal oral verrucal lesions were selected from surgical and histopathological records. Results: Nine patients of diverse ethnicity with 43 biopsies were reviewed. The mean age at the presentation was 62 years. The most frequent sites affected were gum, sulci, cheek and tongue. Indulgence in risk habits was reported in about 70% of patients. Four cases developed multifocal carcinoma from multifocal leukoplakia. Conclusions: In retrospect, none of the cases fulfilled the original PVL criteria, although three cases were suggestive of PVL. Nevertheless, these findings do not necessarily preclude the existence of PVL as a clinicopathological entity in Malaysian population.

Item Type: Article
Additional Information: Ghazali N, Bakri MM, Zain RB. Aggressive, multifocal oral verrucous leukoplakia: proliferative verrucous leukoplakia or not? Journal of Oral Pathology & Medicine. 2003 Aug;32(7):383-92.
Uncontrolled Keywords: Squamous-cell Carcinoma; Hyperplasia; Lesions; Cavity; Carcinogenesis; Management; Cancers; Mucosa; Tumors
Subjects: R Medicine
R Medicine > RB Pathology
R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User: Prof. Dr. Rosnah Mohd Zain
Date Deposited: 10 Jan 2012 02:02
Last Modified: 20 Oct 2014 01:46
URI: http://eprints.um.edu.my/id/eprint/2364

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