Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches

Salim, Fatimah and Yunus, Yusri Mohd and Anouar, El Hassane and Awang, Khalijah and Langat, Moses and Cordell, Geoffrey A. and Ahmad, Rohaya (2019) Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches. Journal of Natural Products, 82 (11). pp. 2933-2940. ISSN 0163-3864, DOI https://doi.org/10.1021/acs.jnatprod.8b00380.

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Official URL: https://doi.org/10.1021/acs.jnatprod.8b00380

Abstract

The structure elucidation of three new alkaloids named isoformosaninol (1), formosaninol (2), and longiflorine (3), isolated from the leaves of Uncaria longiflora var. pteropoda (Miq.) Ridsdale, along with their biosynthetic pathways are discussed. Their absolute structures were determined through a combination of physical data interpretation and quantum chemical calculations using the time-dependent density functional theory (TDDFT) method. Copyright © 2019 American Chemical Society and American Society of Pharmacognosy.

Item Type: Article
Funders: Malaysian Government grant through the Fundamental Research Grant Scheme Fund, Grant 600-RMI/FRGS 5/3 (49/2013), Universiti Teknologi MARA through BESTARI Grant 5/3/BESTARI (0028/2016) and GIP Grant 600-IRMI-MYRA 5/3/GIP (088/2017)
Uncontrolled Keywords: Uncaria; Cat's Claw; U tomentosa
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 24 Jan 2020 01:08
Last Modified: 24 Jan 2020 01:08
URI: http://eprints.um.edu.my/id/eprint/23560

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