Tan, Daryl and Mohamad, Nurul Ashikin and Wong, Yin How and Yeong, Chai Hong and Cheah, Peng Loon and Sulaiman, Norshazriman and Abdullah, Basri Johan Jeet and Fabell, Mohd Kamil and Lim, Kok Sing (2019) Experimental assessment on feasibility of computed tomography-based thermometry for radiofrequency ablation on tissue equivalent polyacrylamide phantom. International Journal of Hyperthermia, 36 (1). pp. 553-560. ISSN 0265-6736, DOI https://doi.org/10.1080/02656736.2019.1610800.
Full text not available from this repository.Abstract
Purpose: This study aimed to evaluate the effects of various computed tomography (CT) acquisition parameters and metal artifacts on CT number measurement for CT thermometry during CT-guided thermal ablation. Methods: The effects of tube voltage (100–140 kVp), tube current (20–250 mAs), pitch (0.6–1.5) and gantry rotation time (0.5, 1.0 s) as well as metal artifacts from a radiofrequency ablation (RFA) needle on CT number were evaluated using liver tissue equivalent polyacrylamide (PAA) phantom. The correlation between CT number and temperature from 37 to 80 °C was studied on PAA phantom using optimum CT acquisition parameters. Results: No statistical significant difference (p > 0.05) was found on CT numbers under the variation of different acquisition parameters for the same temperature setting. On the other hand, the RFA needle has induced metal artifacts on the CT images of up to 8 mm. The CT numbers decreased linearly when the phantom temperature increased from 37 to 80 °C. A linear regression analysis on the CT numbers and temperature suggested that the CT thermal sensitivity was –0.521 ± 0.061 HU/°C (R2 = 0.998). Conclusion: CT thermometry is feasible for temperature assessment during RFA with the current CT technology, which produced a high CT number reproducibility and stable measurement at different CT acquisition parameters. Despite being affected by metal artifacts, the CT-based thermometry could be further developed as a tissue temperature monitoring tool during CT-guided thermal ablation. © 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Postgraduate Research Grant [PO030-2015B and PO057-2015B] |
| Uncontrolled Keywords: | CT-based thermometry; noninvasive thermometry; radiofrequency ablation; liver equivalent phantom |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine Deputy Vice Chancellor (Research & Innovation) Office > Photonics Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Jan 2020 02:27 |
| Last Modified: | 06 Jan 2020 02:27 |
| URI: | http://eprints.um.edu.my/id/eprint/23311 |
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