Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan

Tan, Kae Yi and Liew, Sin Teng and Tan, Qian Yi and Abdul-Rahman, Farah Nadhirah and Azmi, Nor Izzati and Sim, Si Mui and Tan, Nget Hong and Khomvilai, Sumana and Sitprija, Visith and Tan, Choo Hock (2019) Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan. Toxicon, 160. pp. 55-58. ISSN 0041-0101, DOI https://doi.org/10.1016/j.toxicon.2019.02.010.

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Official URL: https://doi.org/10.1016/j.toxicon.2019.02.010

Abstract

Gel filtration chromatography and gel electrophoresis revealed minimal protein degradation in lyophilized antivenoms which were 2-year expired (Hemato Polyvalent, Neuro Polyvalent; Thailand) and 18-year expired (Hemato Bivalent, Neuro Bivalent; Taiwan). All expired antivenoms retained immunological binding activity, and were able to neutralize the hemotoxic or neurotoxic as well as lethal effects of the homologous snake venoms. The findings show that antivenoms under proper storage conditions may remain relatively stable beyond the indicated shelf life. © 2019 Elsevier Ltd

Item Type: Article
Funders: University of Malaya for the provision of research facilities and funding (Grants no. RG352-15AFR and BKS003-2017)
Uncontrolled Keywords: Antivenins; Chromatography, Gel; Drug Stability; Electrophoresis, Polyacrylamide Gel; Neutralization Tests; Snake Venoms; Taiwan; Thailand
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 03 Jan 2020 05:54
Last Modified: 03 Jan 2020 05:54
URI: http://eprints.um.edu.my/id/eprint/23302

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