Tan, Kae Yi and Liew, Sin Teng and Tan, Qian Yi and Abdul-Rahman, Farah Nadhirah and Azmi, Nor Izzati and Sim, Si Mui and Tan, Nget Hong and Khomvilai, Sumana and Sitprija, Visith and Tan, Choo Hock (2019) Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan. Toxicon, 160. pp. 55-58. ISSN 0041-0101, DOI https://doi.org/10.1016/j.toxicon.2019.02.010.
Full text not available from this repository.Abstract
Gel filtration chromatography and gel electrophoresis revealed minimal protein degradation in lyophilized antivenoms which were 2-year expired (Hemato Polyvalent, Neuro Polyvalent; Thailand) and 18-year expired (Hemato Bivalent, Neuro Bivalent; Taiwan). All expired antivenoms retained immunological binding activity, and were able to neutralize the hemotoxic or neurotoxic as well as lethal effects of the homologous snake venoms. The findings show that antivenoms under proper storage conditions may remain relatively stable beyond the indicated shelf life. © 2019 Elsevier Ltd
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya for the provision of research facilities and funding (Grants no. RG352-15AFR and BKS003-2017) |
| Uncontrolled Keywords: | Antivenins; Chromatography, Gel; Drug Stability; Electrophoresis, Polyacrylamide Gel; Neutralization Tests; Snake Venoms; Taiwan; Thailand |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Jan 2020 05:54 |
| Last Modified: | 03 Jan 2020 05:54 |
| URI: | http://eprints.um.edu.my/id/eprint/23302 |
Actions (login required)
 |
View Item |
