Tan, Loh Teng Hern and Mahendra, Camille Keisha and Yow, Yoon Yen and Chan, Kok Gan and Khan, Tahir Mehmood and Lee, Learn Han and Goh, Bey Hing (2019) Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants. MicrobiologyOpen, 8 (10). e859. ISSN 2045-8827, DOI https://doi.org/10.1002/mbo3.859.
Full text not available from this repository.Abstract
Microbial natural products serve as a good source for antioxidants. The mangrove-derived Streptomyces bacteria have been evidenced to produce antioxidative compounds. This study reports the isolation of Streptomyces sp. MUM273b from mangrove soil that may serve as a promising source of antioxidants and UV-protective agents. Identification and characterization methods determine that strain MUM273b belongs to the genus Streptomyces. The MUM273b extract exhibits antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging activities and also metal-chelating activity. The MUM273b extract was also shown to inhibit the production of malondialdehyde in metal-induced lipid peroxidation. Strong correlation between the antioxidant activities and the total phenolic content of MUM273b extract was shown. In addition, MUM273b extract exhibited cytoprotective effect on the UVB-induced cell death in HaCaT keratinocytes. Gas chromatography–mass spectrometry analysis detected phenolics, pyrrole, pyrazine, ester, and cyclic dipeptides in MUM273b extract. In summary, Streptomyces MUM273b extract portrays an exciting avenue for future antioxidative drugs and cosmeceuticals development. © 2019 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.
| Item Type: | Article |
|---|---|
| Funders: | External Industry Grants from Biotek Abadi Sdn Bhd (vote no. GBA‐81811A), University Malaya Research Grant (PPP grants PG088‐2015B and PG089‐2015B and JBK grant GA002‐2016), MOSTI eScienceFund Grant (Project No. 02‐02‐10‐SF0215) |
| Uncontrolled Keywords: | antioxidant; cosmeceutical; mangrove; Streptomyces; UV-protective |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history Q Science > QR Microbiology |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Jan 2020 05:41 |
| Last Modified: | 03 Jan 2020 05:41 |
| URI: | http://eprints.um.edu.my/id/eprint/23300 |
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