Association of HLA locus variant in Parkinson's disease

Zhao, Y. and Gopalai, A.A. and Ahmad-Annuar, A. and Teng, E.W.L. and Prakash, K.M. and Tan, L.C.S. and Au, W.L. and Li, H.H. and Lim, Shen Yang and Lim, Soo Kun and Chong, Yip Boon and Tan, Li Ping and Ibrahim, N.M. and Tan, E.K. (2012) Association of HLA locus variant in Parkinson's disease. Clinical Genetics, 84 (5). pp. 501-504. ISSN 0009-9163

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Official URL: https://doi.org/10.1111/cge.12024

Abstract

A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR)=0.77, 95% confidence interval (CI)=0.62, 0.96, p=0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD. © 2012 John Wiley & Sons A/S.

Item Type: Article
Uncontrolled Keywords: Chinese; Gene; Parkinson's disease; Polymorphism
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 20 Nov 2019 01:44
Last Modified: 20 Nov 2019 01:44
URI: http://eprints.um.edu.my/id/eprint/23071

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