Mathematical models for prediction of active substance content in pharmaceutical tablets and moisture in wheat

Soh, C.S.; Raveendran, P.; Mukundan, R. (2008) Mathematical models for prediction of active substance content in pharmaceutical tablets and moisture in wheat. Chemometrics and Intelligent Laboratory Systems, 93 (1). pp. 63-69. ISSN 0169-7439

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Abstract

In the prediction of active substance content in pharmaceutical tablets and moisture in wheat, a very large number of wavelengths were used. Hence, a method to identify a limited number of wavelengths was developed. We introduce a novel approach that uses the discrete cosine transform (DCT) for this purpose. The data was obtained using near infrared spectrometer. From the DCT coefficients, a limited number was chosen as predictor variables to be used in partial least square (PLS) regression. Likewise, a limited number of DFT coefficients were also used in the PLS regression. The performance of combining the DCT with PLS was compared with that of the PLS model using the full spectral data and with the discrete Fourier transform (DFT). The results showed that the PLS model using DCT coefficients produced lower root mean square error than using the full NIR spectral data with the PLS and also the DFT. (C) 2008 Elsevier B.V. All rights reserved.

Item Type: Article
Journal or Publication Title: Chemometrics and Intelligent Laboratory Systems
Additional Information: collaboration between 1. Univ Malaya, Dept Elect Engn, Fac Engn, Kuala Lumpur, Malaysia 2. Univ Canterbury, Dept Comp Sci & Software Engn, Christchurch 1, New Zealand
Uncontrolled Keywords: Discrete Cosine Transform; Pharmaceutical Tablets; Wheat; NIR Spectra
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Divisions: Faculty of Engineering
Depositing User: Mr. Faizal Hamzah
Date Deposited: 01 Dec 2011 11:44
Last Modified: 01 Dec 2011 11:44
URI: http://eprints.um.edu.my/id/eprint/2303

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