Win, Yip Foo and Teoh, Siang Guan and Tengku-Muhammad, Tengku Sifzizul and Ha, Sie Tiong and Sivasothy, Yasodha (2010) Synthesis and structural characterization of organotin (IV) complexes derived of 4- (Diethylamino) benzoic acid: Cytotoxic assay on human liver carcinoma cells (HepG2). Australian Journal of Basic and Applied Sciences, 4 (6). pp. 1383-1390. ISSN 1991-8178,
Full text not available from this repository.Abstract
Organotin(IV) carboxylate complexes derived from 4-(diethylamino) benzoic acid, 4-[N(C2H5)2]C6H4COOH have been successfully synthesized. Two types of diorganotin(IV) complexes {4-[N(C2H5)2]C6H4COO}2(R)2Sn (R= methyl 1, butyl 2), [{4-[N(C2H5)2]C6H4COO(C4H9)2Sn}2O]2 dimer 3 and 4-[N(C2H5)2]C6H4COO(C6H5)3Sn 4 were successfully synthesized and obtained in solid state. The acid and complexes 1-4 obtained were characterized quantitatively using C, H, N and Sn elemental analysis as well as spectroscopic methods such as infrared (FTIR) and nuclear magnetic resonance (1H, 13C & 119Sn NMR). Results of the infrared and NMR spectroscopy on the acid and complexes showed that the coordination took place via oxygen atoms from the carboxylate group. As a result, the tin atom of complex 2 is six-coordinated, complex 4 is four-coordinated and tin atoms of complex 3 are five- and six-coordinated. With the exceptional case the tin atom of complex 1 exhibited five and six coordination in solution state which may be attributed from the dynamic stage or partial disassociation bonding of carboxylate anion. From the cytotoxic assay study, complex 4 revealed a significant result compared to complexes 1-3. © 2010, INSInet Publication.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Synthesis; Characterization; Cytotoxic assay |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Nov 2019 02:05 |
| Last Modified: | 14 Nov 2019 02:05 |
| URI: | http://eprints.um.edu.my/id/eprint/22984 |
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