Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies

Voon, Siew Hui and Kue, Chin Siang and Imae, Toyoko and Saw, Wen Shang and Lee, Hong Boon and Kiew, Lik Voon and Chung, Lip Yong and Yusa, Shin-ichi (2017) Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies. International Journal of Pharmaceutics, 534 (1-2). pp. 136-143. ISSN 0378-5173, DOI https://doi.org/10.1016/j.ijpharm.2017.10.023.

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Official URL: https://doi.org/10.1016/j.ijpharm.2017.10.023

Abstract

Previously reported amphiphilic diblock copolymer with pendant dendron moieties (P 71 D 3 ) has been further evaluated in tumor-bearing mice as a potential drug carrier. This P 71 D 3 -based micelle of an average diameter of 100 nm was found to be biocompatible, non-toxic and physically stable in colloidal system up to 15 days. It enhanced the in vitro potency of doxorubicin (DOX) in 4T1 breast tumor cells by increasing its uptake, by 3-fold, compared to free DOX. In 4T1 tumor-bearing mice, the tumor growth rate of P 71 D 3 /DOX (2 mg/kg DOX equivalent) treated group was significantly delayed and their tumor volume was significantly reduced by 1.5-fold compared to those treated with free DOX. The biodistribution studies indicated that P 71 D 3 /DOX enhanced accumulation of DOX in tumor by 5- and 2-fold higher than free DOX treated mice at 15 min and 1 h post-administration, respectively. These results suggest that P 71 D 3 micelle is a promising nanocarrier for chemotherapeutic agents.

Item Type: Article
Funders: UNSPECIFIED
Uncontrolled Keywords: Diblock copolymer micelles; Doxorubicin; Anticancer; Drug delivery; Biodistribution
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 24 Oct 2019 05:05
Last Modified: 24 Oct 2019 05:05
URI: http://eprints.um.edu.my/id/eprint/22841

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