Voon, Siew Hui and Kue, Chin Siang and Imae, Toyoko and Saw, Wen Shang and Lee, Hong Boon and Kiew, Lik Voon and Chung, Lip Yong and Yusa, Shin-ichi (2017) Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies. International Journal of Pharmaceutics, 534 (1-2). pp. 136-143. ISSN 0378-5173, DOI https://doi.org/10.1016/j.ijpharm.2017.10.023.
Full text not available from this repository.Abstract
Previously reported amphiphilic diblock copolymer with pendant dendron moieties (P 71 D 3 ) has been further evaluated in tumor-bearing mice as a potential drug carrier. This P 71 D 3 -based micelle of an average diameter of 100 nm was found to be biocompatible, non-toxic and physically stable in colloidal system up to 15 days. It enhanced the in vitro potency of doxorubicin (DOX) in 4T1 breast tumor cells by increasing its uptake, by 3-fold, compared to free DOX. In 4T1 tumor-bearing mice, the tumor growth rate of P 71 D 3 /DOX (2 mg/kg DOX equivalent) treated group was significantly delayed and their tumor volume was significantly reduced by 1.5-fold compared to those treated with free DOX. The biodistribution studies indicated that P 71 D 3 /DOX enhanced accumulation of DOX in tumor by 5- and 2-fold higher than free DOX treated mice at 15 min and 1 h post-administration, respectively. These results suggest that P 71 D 3 micelle is a promising nanocarrier for chemotherapeutic agents.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Diblock copolymer micelles; Doxorubicin; Anticancer; Drug delivery; Biodistribution |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 24 Oct 2019 05:05 |
| Last Modified: | 24 Oct 2019 05:05 |
| URI: | http://eprints.um.edu.my/id/eprint/22841 |
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